Applications of Adenine and Adenine Derivatives

Adenine, which exists as a base in nucleic acids in living organisms, has received extensive attention from biochemists and organic synthesists in recent years because of its favorable biological activity. Especially in antiviral and cancer cell inhibition, adenine derivatives have obvious effects and attractive prospects for clinical applications. With the continuous synthesis of various adenine derivatives, scientists have also discovered that they have more biological activities. For example, it has been found that adenine derivatives also have good antibacterial activity. N9-(2-chloro-6-fluorobenzyl) adenine is an effective antibacterial reagent. N9- (acetaldehyde thiosemicarbazone) adenine has an antibacterial effect on Escherichia coli and Staphylococcus aureus. Apart from the pharmaceutical aspect, adenine derivatives have many applications in other fields. In agriculture, they are used as herbicides. Adenine derivatives are also used in the light stabilizer industry because of the good light stabilizing effect of the base as a natural product.

Nucleoside-based Adenine Derivative Production Services at CD BioGlyco

CD BioGlyco strives to provide high-quality adenine derivative production services and innovative products. We produce novel adenine derivatives from the natural base adenine through various modifications. We successfully produce various adenine derivatives through various modification pathways such as the introduction of an aromatic ring.

• Adenine derivative production service

Natural bases have certain defects, such as poor solubility, not well mixed with substrate materials, poor thermal stability, narrow UV absorption range, etc. We use adenine as raw material and design reaction routes to produce various adenine derivatives. Adenine derivatives are mainly produced by chemical methods. The target compounds are finally produced through various reactions such as esterification, condensation, and substitution. In order to find a synthetic route with mild conditions, high yield, promising industrialization, etc., we design different routes for comparative analysis. Our modifications include but are not limited to the following. We also test the biological activities of the target products, including antibacterial, antiviral, and antitumor activities, etc.

Fig.1 Several modifications of adenine. (CD BioGlyco)

• Production of biologically active adenine derivatives is carried out by bonding compounds with heteroatoms at 6 and 9 iso-positions of adenine.
• The aryl rings are modified with different types of substituents and the experimental conditions are studied in series to find the optimum reaction conditions.
• We produce novel derivatives by splicing substructural moieties with a wide range of biological activities (CONHN=CH, etc.) with adenine using an active substructure linkage method.

• Adenine derivatives products

We optimize the production process of different adenine derivatives to maximize the yield as much as possible. Our adenine derivative products include 3-methyladenine, adenine hemisulfate salt, β-nicotinamide adenine dinucleotide hydrate, β-nicotinamide adenine dinucleotide phosphate hydrate, etc. The structures of each compound are confirmed by IR, ¹H NMR, ¹³C NMR, and HRMS.

Applications

• As an advanced analytical method, fluorescence analysis is widely used in various fields of life science research, such as clinical diagnosis and drug discovery. Adenine derivatives play an important role in the development of fluorescence analysis.
• Adenine derivatives play an important role in the development of new pesticide lead compounds, herbicides, and light stabilizers.
• The study of adenine modification and its related diseases is one of the hotspots. The production of novel adenine derivatives has an important role in the study of the mechanism of disease occurrence.

Highlights

• We have first-class production equipment and a quality management system. The products are produced quickly and with high quality.
• We have the ability to overcome difficult chemical production and will design exclusive synthetic pathways according to clients' requirements.
• Adenine derivatives play an important role in regulating basic cellular processes and gene expression for a variety of physiological functions. Their production helps drive the development of therapeutics for diseases.

CD BioGlyco is committed to providing high-quality custom production services for various compounds. We have professional team management and an outstanding R&D team to ensure the custom production of adenine derivatives. Besides adenine derivative, we also provide Cytosine Derivative and Cytidine Derivative Production Services. If you are interested in our adenine derivatives products, please feel free to contact us at any time.