Quality Services Are Our Aim

CD BioGlyco offers a wide range of Cytidine derivatives. We produce various cytidine derivatives mainly by chemical methods. We also produce cytidine derivatives enzymatically.

Fig.1 Cytidine derivative custom production process. (CD BioGlyco)

• Cytidine derivative production service at CD BioGlyco

We specialize in acylation, phosphorylation, etherification, alkylation, etc. Natural cytidine, 5-fluorouracil (5-Fu), 5-azacytosine, etc., are raw materials. We produce various cytidine derivatives through various chemical reactions to expand the derivatives library. We aim to develop routes that are simple, low-cost, less polluting to the environment, and suitable for industrial production.

In addition, we produce new cytidine derivatives with stronger bioactivity. It is shown that the best-combined results of activity and toxicity are obtained when the N4 position on the cytosine base is N-pentoxy-carbonyl. In order to further study the conformational relationship of such compounds and to find highly active compounds, we design substitutions on the pyrimidine base ring such as alkylamine, alkoxy, etc. Azacitidine is a cytidine analog. We develop a route with a short and simple operation using 5-azacytosine as raw material. In addition to the production and structural analysis, we also complete the subsequent bioactivity assay experiments according to the client's needs.

Enzymes act as highly selective catalysts that enable selective reactions at a particular site. Enzymatic synthesis methods require mild reaction conditions. The reaction process is generally non-toxic, non-polluting, and has low energy consumption. It is an environmentally friendly method and has good application prospects in green chemical industrial production. We also study the application of the enzymatic synthesis method.

• Cytidine derivative products

Our products include 2',3'-DI-O-acetyl-5'-deoxy-5-fluorocytidine, 2'-O-(2-methoxyethyl) cytidine, cytidine 3'(2')-monophosphate, 1'-¹³C Cytidine, cytidine-2'-¹³C, cytidine-5-diphosphate sodium salt, etc. All products are confirmed by IR, ¹³C NMR, ¹H NMR, and MS.

Applications

• High-quality cytidine derivatives are used to develop cytidine derivative monomers for the preparation of RNA long chains.
• Cytidine derivatives may inhibit viral proliferation to some extent. Their production plays a vital role in the development of more active compounds such as anti-tumor and anti-poisoning.
• Cytidine derivatives may regulate gene expression by decreasing the methylation level of DNA, thus epigenetically regulating the growth and development of organisms.

Highlights

• We specialize in a variety of chemical reactions, including phosphorylation, alkylation, and etherification. We have the ability to produce a wide range of structurally complex compounds.
• We have a wide range of cytidine derivatives and will provide detailed technical guidance and after-sales service.
• Diseases are associated with alterations in genetics and epigenetics. Cytidine derivatives help to study their correlation with disease occurrence.

CD BioGlyco has a specialized R&D team to produce various cytidine derivatives. We are committed to supporting your scientific research by precisely meeting your production needs. In addition to cytidine derivatives, we also produce Guanosine Derivatives, Guanine Derivatives, etc. If you would like to know more about the production of cytidine derivatives, the price and parameters of the products, etc., please feel free to contact us.