Nucleoside-based Guanosine Derivative Production Services at CD BioGlyco

CD BioGlyco is experienced in guanosine production. To meet the needs of various syntheses, we specialize in first-class experimental instruments and a professional team. Our research on Guanosine derivatives covers a wide range of areas, including the production of novel derivatives, the detection of biological activities, the study of the self-assembly of guanosine derivatives, etc.

Fig.1 Studies on the production and application of guanosine derivatives. (CD BioGlyco)

• Guanosine derivatives production service

The bases and sugar groups of the guanosine can be chemically modified. We produce new guanosine derivatives by introducing certain groups at specific sites or by changing the original structure, such as 2'-O-methyl modification, C-8 position modification of bases, etc. In order to obtain the route with simple operation, low cost, less pollution to the environment, and green chemistry, we will design various reaction processes and optimize them continuously.

• Production services based on the application of guanosine derivatives

In order to produce guanosine derivatives with different functions and expand their applications, we modify the bases and sugar groups. According to the client's request, we will complete all or part of the experiments from the synthetic design to the application study.

• 2'-O-methyl-modified ribonucleoside is the basic raw material for the production of second-generation antisense oligonucleotides. As an important drug intermediate, the study of the production of this type of ribonucleoside derivatives is of great practical significance. In order to expand their applications in medicine, we produce various 2'-O-methyl-modified derivatives.
• It is found that some guanosine derivatives can play a role in inhibition such as human multiple myeloma cells. We will modify bases and sugar groups of guanosines, 2-hydroxyadenosine, and others to obtain new compounds with antitumor activity and the ability to be used as fluorescent probes. Once the client's needs are clearly defined, we perform all the experiments from the early production of the compound to the detection of its antitumor activity.
• Supramolecular structures formed by self-assembly exhibit properties that often exceed or differ from the simple sum of the properties of their individual components. This approach has also been extensively studied. Due to the fact that the side chains can be functionalized, guanosine and its derivatives are considered to be ideal building blocks for the formation of complex and controllable structures with rigidity. It is found that guanosine derivatives can form a variety of structures under specific conditions. The formation of supramolecular structures by deoxyguanosine derivatives has also been reported. We have produced various guanosine derivatives and studied their self-assembly behavior.

Applications of Nucleoside-based Guanosine Derivatives

• Long non-coding RNAs are prognostic factors in malignant tumors. Guanosine derivatives are used for the research of tumor progression.
• As oxidative stress metabolites, guanosine derivatives are used to investigate their diagnostic value as primary screening markers for disease.
• Guanosine derivatives are used to study self-assembly behavior, biosynthesis, roles between DNA and RNA, etc.

Highlights

• We use an optimized purification process. Experimental progress is detected and updated in real time during production. High product quality and purity.
• The production of existing nucleoside analogs often involves the modification of naturally occurring sugar rings. This fundamentally limits the types of nucleoside analogs. We modify guanosine derivatives on the basis of guanosine.
• Nucleoside analogs as inhibitors of nucleic acid metabolism have good antiviral and antitumor effects. Good quality guanosine derivatives will help in the development of more effective antiviral and antitumor drugs.

CD BioGlyco has strict standardized management from raw materials and production to testing. We are committed to escorting your research applications and the commercialization process. In addition to guanosine derivatives, we also custom manufacture various Guanine Derivatives and Guanosine Derivatives. Welcome to contact us for more information about guanosine derivatives production, structure analysis, etc.