Guanine Derivatives in Medicine

Guanine is one of the four major nucleobases found in the nucleic acids DNA and RNA. It plays a key role in cells. Many guanine derivatives have been used as anticancer and antiviral agents for decades. Drugs made from guanine derivatives as pharmaceutical intermediates have shown particular efficacy against cancer, AIDS, etc. Among many guanine derivatives, some N²-substituted guanines also exhibit intriguing biological activities. Several N²-substituted guanines and their nucleosides exhibit selective inhibitory activity against HSV type 1 (HSV1) thymidine kinase (TK) both in vitro and in vivo relative to the human enzyme.

Nucleoside-based Guanine Derivative Production Service at CD BioGlyco

CD BioGlyco has experience in producing compounds with complex and novel structures. We always focus on innovation, with a strong emphasis on improving our own R&D capabilities and product quality.

Fig.1 Custom production process of guanine derivatives. (CD BioGlyco)

• Application-related guanine derivatives production service

With the continuous research of guanine derivatives, it is found that the modification of guanine can show a variety of pharmaceutical activities. The modification of guanine has also become a research direction to obtain novel drug molecules. Our research team is experienced in chemical synthesis and provides a variety of efficient guanine derivative production services.

Guanine analogs have been widely used in anticancer research for decades. They have a wide range of antitumor activities and act mainly by inducing apoptosis and inhibiting DNA synthesis. Several drugs with antitumor activity have been developed, such as 8-bromo-9-(β-D-xylofuranosyl) guanine, 8-hydroxyguanine, 7-(Butyn-2-yl)-7,8-dihydro-8-oxo-9-(β-D-xylofuranosyl) guanine, etc. We produce low-toxicity guanine derivatives that are used in cancer therapy research through various chemical reactions such as acylation and alkylation reactions.

In addition to antitumor, it has been found that some N²-substituted guanine derivatives are better in other activities, such as thymidine kinase inhibitory activity, anti-microbial activity, and cell cycle protein-dependent kinase inhibitory activity. In addition, some N²-substituted guanines can also be used as synthetic intermediates for the preparation of molecular biology tools, diagnostic agents, etc. Based on the reported routes, some optimizations and improvements are made to produce N²-substituted guanine derivatives, such as various N²-alkylated guanines.

• Guanine derivatives products

We optimize the synthetic routes of guanine derivatives in order to facilitate industrial production and reduce the cost of raw materials. Our products include 8-hydroxyguanine, 8-bromo-9-(β-D-xylofuranosyl) guanine, 8-benzyloxy-9-(β-D-xylofuranosyl) guanine, O⁶-benzylguanine and so on. All products have been confirmed by ¹H NMR, ESI-MS, or ¹³C NMR.

Applications

• DNA damage is closely associated with many biological pathways, such as gene mutation, genotoxicity, and tumorigenesis. The production of guanine derivatives is used to explore the detection of DNA damage.
• Production of guanine derivatives is used to develop pharmaceutical intermediates with specific structures or compounds that can be used for disease diagnosis.
• The design and production of guanine derivatives and their application in the field of self-assembly is a hot research topic in supramolecular chemistry. Their design and production are of great importance.

Highlights

• We are equipped with complete experimental facilities for the production of nucleoside derivatives, with a wide range of advanced instrumentation such as NMR, HPLC, and LC-MS.
• We have rich experience in the production of complex chemicals and are capable of meeting the challenges of synthesizing various complex compounds.
• Oxidative damage causes many forms of DNA damage. The production of guanine derivatives helps to study the mechanisms associated with the development of diseases.

CD BioGlyco has been specializing in the research, development, production, and sales of medically related nucleoside derivatives for many years. In addition to guanine derivatives, we also provide Uridine Derivative and Uracil Derivative Production Services. if you would like to know the price and production method of various guanine derivatives, please feel free to contact us for the inquiry.