Significance of Adenosine Derivatives Production

Adenosine, as an endogenous nucleoside spread throughout the human body, plays an important role in human metabolism. Its derivatives are also an important class of active substances, which are of great significance in the research, development, and application of antitumor drugs. Since nucleoside drugs still have defects such as many side effects, rapid metabolism, and weak absorption, the search for more efficient nucleoside compounds is a research hotspot in the scientific community. Researchers are committed to the modification of adenosine in an attempt to develop drugs with anti-tumor and other activities. A part of the drugs has been developed. Overall, adenosine analogs are expected to be potential antitumor and other agents.

We Are the Best Choice

CD BioGlyco has a complete range of laboratory instruments and reagents designed to assist our clients in the production of adenosine derivatives. With proficient problem-solving skills and a high success rate, we are capable of providing our clients with high-quality customized services for adenosine derivatives. In addition to the target compounds, we also attach test results records.

• Nucleoside-based adenosine derivative production service at CD BioGlyco

There are 3 main methods to produce adenosine analogs, namely chemical synthesis, biotransformation, and structural modification. We mainly use the structural modification method to produce the derivatives. Adenosine consists of both a sugar group and a base. We modify adenosine in two main ways to obtain biologically active compounds. One is the structural modification of the sugar or base of the nucleoside structure. The other is the simultaneous modification of both the sugar group and the base.

• Glycosyl group Modification

We modify on D- or L-type furanose. The furanose is also transformed into carbocyclic, pyranosyl, four-membered oxygen heterocyclic, five-membered sulfur heterocyclic, chain structures, etc.

• Base Modification

The bases play a decisive role in the activity of adenosine antiviral drugs. Base modification is also one of the major avenues in the development of adenosine antiviral drugs. This includes the replacement of carbon atoms on the base ring by other heteroatoms and the introduction of other substituents on the base ring.

• Simultaneous modification of base and sugar group

The structural difference between the compound and the natural adenosine after the simultaneous modification of the base and the sugar group is greater. Its toxicity will be reduced.

Fig.1 Adenosine derivative production process. (CD BioGlyco)

• Adenosine derivative products

We successfully produce various adenosine derivatives, such as 6-substituted adenosine derivatives, 8-substituted adenosine derivatives, etc. through structural modification. We design and optimize the pathway to ensure the best yield according to the client's requirements.

• 6-Substituted adenosine derivatives

We produce adenosine derivatives from adenosine by structural modification of its N6-position. Production of adenosine derivative. we characterize its compound structure by ¹H NMR, ESI-MS, ¹³C NMR, etc.

• 8-Substituted adenosine derivatives

These compounds have been shown to have very high antitumor activity, e.g., 8-chloroadenosine and 8-amino-adenosine. We produce 8-substituted adenosine derivatives with different structures using adenosine as the raw material. After the production, we characterize the structures of the compounds by ¹H NMR, ESI-MS, and ¹³C NMR.

Applications of Nucleoside-based Adenosine Derivative Production Service

• Production of novel adenosine derivatives contributes to the development of drugs with potential antiviral activity.
• The optimized methodology facilitates the production of high-quality adenosine derivatives, which are used to develop compounds that can be used in the food sector.
• Molecular and cellular mechanisms remain to be elucidated. Production of adenosine derivatives is used to study their correlation with disease development.

Highlights

• We have a technologically advanced and experienced R&D team with flexible research directions. A wide range of complex compounds can be produced.
• Structural modification of adenosine helps to develop new drugs. We have a wide variety of modifications to adenosine. Modification of bases, sugar groups, etc., can be done.
• Adenosine is a naturally occurring molecule in the human body. Adenosine and its analogs have definite antitumor activity. Production of adenosine derivatives helps in the development of anticancer drugs.

CD BioGlyco is committed to being your scientific partner in providing the necessary theoretical and experimental support for the production of adenosine derivatives. Please feel free to contact us at any time with your requirements.