Overview of Uridine

Uridine, with the chemical formula C9H12N2O6, is a small molecule metabolite composed of uracil and ribose, a type of nucleoside. The appearance of uridine is white needle-like crystals or powder. It is commonly found in foods such as vegetable broccoli, tomatoes, and mushrooms, as well as animal livers and dairy products. Its derivatives (a variety of pyrimidine nucleotides) are used in the synthesis of genetic material such as RNA and DNA. Uridine has a wide range of uses. Uridine is a relevant component of nucleic acid in animal cells and can increase the level of antibodies in the body. Animal experiments show that uridine and inosine can promote cardiomyocyte metabolism, accelerate protein, nucleic acid biosynthesis, and energy production, and promote and improve brain cell metabolism. Uridine plays a significant role in medical treatment.

Fig.1 The biosynthetic pathway of uridine in E. coli and the scheme for construction of the uridine production strain. (Wu, et al., 2018)

Nucleoside-based Uridine Production Service at CD BioGlyco

Uridine plays a key role in the metabolism of human tissues, so it is essential to study the production of uridine. At CD BioGlyco, we have comprehensively studied the production, testing, and application of uridine.

• Production of uracil nucleosides
  CD BioGlyco offers two routes: Chemical Synthesis and biosynthesis.
  
  • In chemical synthesis, uridine is produced by condensation reaction under catalytic conditions using the corresponding bases as the main raw materials.
  • For biosynthesis, the uridines are also synthesized by fermentation of different strains of bacteria using the bases as substrates.
• Structural characterizations
  At CD BioGlyco, we have professional testing instruments to perform qualitative and quantitative testing of uridine. IR, NMR, and UV are suitable methods for qualitative testing of uridine, while thin layer chromatography (TLC), ion exchange resin (IER), and HPLC are excellent methods for quantitative testing of uridine.

In addition, the uridine we produce could be applied to the preparation of uridine triphosphate (UTP).

Fig.2 A full range of services of uridine. (CD BioGlyco)

Applications

• Uridine nucleosides could be used in the research of antitumor drugs.
• Uridine nucleosides are used in the research of the treatment of human blood vessel diseases.
• Uridine nucleosides are used in the research of anemia treatment.

Advantages

• The production of uridine helps researchers to explore its structure and range of applications.
• The production of uracil nucleosides helps researchers to investigate the structure and function of bases as well as nucleosides.

CD BioGlyco offers a comprehensive range of uridine production services to ensure time-saving and efficiency. All of our synthesized products undergo numerous quality tests to ensure that the products supplied to our clients are of high purity and quality. If you are interested in our services, please feel free to contact us for more details.