Nucleoside & Nucleotide Synthesis Service

Nucleoside and Nucleotide

Nucleotides encompass mono-, di-, or tri-phosphorylated nucleosides, with nucleosides composed of a nitrogenous base (purine, pyrimidine, or pyridine) and a ribose or deoxyribose sugar. These entities hold significant relevance in biological and chemical realms, constituting nucleic acids and influencing cellular processes. Nucleotides, categorized as purines and pyrimidines, differ in nucleobase composition and formation pathways. Despite their paramount importance in biology, nucleotide synthesis involves intricate regulation to maintain essential pools for genome integrity. Nature adeptly handles their synthesis and polymerization, yet recreating these processes under mild, prebiotically plausible, and straightforward lab conditions-sans activation remains a challenge. Navigating this complexity promises deeper insights into the origins of life and synthetic biology possibilities.

Fig.1 Metabolic pathway for nucleotide synthesis. (Kapoor & Varshney, 2020)

Nucleoside & Nucleotide Synthesis Service at CD BioGlyco

There are several approaches to synthesizing nucleosides and nucleotides such as chemical synthesis methods, enzymatic synthesis methods, cell factory synthesis methods, and so on. Based on our previous development of a synthesis and analysis platform, CD BioGlyco has built a well-equipment lab and employed skilled researchers that ensure we have the ability to provide high-quality outcomes. Moreover, CD BioGlyco also provides other Custom Sugar-nucleotide Synthesis Services including Custom Oligonucleotide Synthesis Services, Polynucleotide Synthesis Services, and Nucleoside & Nucleotide Modification Services. CD BioGlyco aims to offer excellent custom nucleoside & nucleotide synthesis proposals for our clients.

Nucleoside Chemical Synthesis Service

Nucleoside chemical synthesis involves assembling nucleobases and sugars, and creating DNA/RNA building blocks through controlled reactions and purification.

Nucleoside Enzymatic Synthesis Service

Nucleoside enzymatic synthesis employs enzymes to catalyze the assembly of nucleobases and sugars forming DNA/RNA building blocks with specificity.

Nucleoside Cell Factory Synthesis Service

Nucleoside cell factory synthesis utilizes genetically engineered cells to produce nucleosides, leveraging cellular machinery for efficient and sustainable production.

Nucleotide Chemical Synthesis Service

Nucleotide chemical synthesis creates DNA/RNA components by coupling nucleosides with phosphates, fundamental for genetic information and cellular functions.

Nucleotide Microbial Synthesis Service

It employs engineered microorganisms to produce nucleotides, harnessing biotechnology for sustainable and cost-effective production.

Nucleotide Enzymatic Digestion Service

Nucleotide enzymatic digestion uses specific enzymes to break down DNA/RNA into smaller fragments, essential for genetic analysis and sequencing.

Applications of Nucleoside & Nucleotide Synthesis Service

Custom nucleosides and nucleotides aid in developing antiviral, anticancer, and therapeutic agents.
Synthetic nucleotides drive mRNA-based vaccine innovation, improving immunization strategies.
Custom nucleotide synthesis supports algorithm development and data analysis in genomics.

Advantages of Us

Our professional R&D team generates custom synthesis proposals for our clients according to their requirements, and we aim to meet our client's needs beyond what they expected.
Our service team is highly responsive and proactive, anticipating customer needs and going above and beyond to ensure a positive experience and satisfaction.

CD BioGlyco aims to be your best assistant in glycan-related research areas and we have developed a synthesis platform for nucleoside and nucleotide synthesis, please feel free to contact us if you are interested in our services and have any questions.

References

Kapoor, I.; Varshney, U. Diverse roles of nucleoside diphosphate kinase in genome stability and Growth Fitness. Current Genetics. 2020, 66(4): 671–682.
Cadassou, O. Cancer and microenvironment: the functional interplay between intra- and extracellular nucleotide metabolisms. Researchgate. 2018.
Hocek, M. Synthesis of base-modified 2′-deoxyribonucleoside triphosphates and their use in enzymatic synthesis of modified DNA for applications in bioanalysis and chemical biology. The Journal of Organic Chemistry. 2014, 79(21): 9914-9921.
Cho, J.S.; et al. Designing microbial cell factories for the production of Chemicals. JACS Au. 2022, 2(8): 1781–1799.
Biscans, A. Exploring the emergence of RNA nucleosides and nucleotides on the early Earth. Life. 2018, 8(4): 57.
Kohlmeier, M. Water-soluble vitamins and nonnutrients. Nutrient Metabolism. 2015, 567–671.

This service is for Research Use Only, not intended for any clinical use.