Nucleoside-based Ribonucleoside Production Service

Nucleoside-based Ribonucleoside Production Service

Characteristics of Ribonucleosides

A nucleoside is formed by condensing pentose sugar with a base. In its structural composition, the first carbon atom of the sugar is linked to the first nitrogen atom of the pyrimidine or the ninth nitrogen atom of the purine by an N-glycosidic bond. The pentose sugar is a furan ring structure, C1 is an asymmetric carbon atom, and the base is perpendicular to the plane of the sugar ring. Nucleosides are a very important class of small biological molecules involved in the molecular mechanisms of gene retention, replication, and transcription in living organisms. This is the main reason why nucleosides are effective in controlling and treating persistent diseases such as AIDS, tumors, and Hepatitis B. This proves that nucleoside compounds have a very high status in the treatment of viruses, and at the same time, nucleoside drugs are recognized as the compounds with the most antiviral potential.

Fig.1 Nucleoside antiviral drug.Fig.1 Nucleoside antiviral drug. (Schina, et al., 2009)

Nucleoside-based Ribonucleoside Production Service at CD BioGlyco

Ribonucleosides play an important role in biogenetics as well as in medicine. At CD BioGlyco, we provide ribonucleoside production services on a long-term basis. Specific services include but are not limited to:

Fig.2 Specifics of ribonucleoside-based nucleoside production.Fig.2 Specifics of ribonucleoside-based nucleoside production. (CD BioGlyco)

Applications

  • Ribonucleosides are used in research for the production of anti-AIDS drugs.
  • Ribonucleosides are used in the study of human immunomodulation.
  • Ribonucleosides are used in biological studies of gene expression.

Advantages

  • The production of ribonucleosides helps to probe deeper into their structure and function.
  • The production of ribonucleosides helps to study the structure of RNA composition.

CD BioGlyco has many years of experience in the production of ribonucleosides and our synthesis laboratory has state-of-the-art synthesis technology to provide custom ribonucleoside production services to clients worldwide. If you are interested in our services, please feel free to contact us directly for more details.

Reference

  1. Schina, R.F.; et al. Cu(I)-catalyzed huge azide−alkyne 1,3-dipolar cycloaddition reaction in nucleoside, nucleotide, and oligonucleotide chemistry. Chem. Rev. 2009, 109(9): 4207-4220.
This service is for Research Use Only, not intended for any clinical use.

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