Importance of Nucleotide Stereo- and Enantio-selective in Biology

Nucleotides are the basic units that make up the nucleic acid molecule, and their steric structure and enantioselectivity are critical for biological function. A nucleotide consists of a nitrogenous base, deoxyribose or ribose, and phosphate. The relative arrangement and stereo-configuration between these components determine the spatial structure and chemical properties of the nucleic acid molecule. In living organisms, nucleic acids fulfill their biological functions by interacting with other molecules, such as proteins and other nucleic acids. Such interactions usually involve the modification of nucleotide-specific sites. For example, the transcriptional activity of DNA, replication stability, and DNA repair processes can be regulated by chemical modifications. In addition, stereo- and enantio-selectivity of nucleotides also have important impacts on the mode of action and effects of drugs stereo- and enantio-selective reaction modifications of nucleotides are of great significance in the fields of biological research, drug development, and chemical biology.

Fig.1 Structure of nucleotide monomers. (Wikipedia)

Nucleotide Stereo- and Enantio-selective Reaction Modification Service at CD BioGlyco

With expertise and extensive experience in the field of Carbohydrate Synthesis, CD BioGlyco has established a comprehensive Glyco™ Synthesis Platform aimed at providing a complete range of high-quality products and services to clients around the world. The specific services we offer include but are not limited to the following:

• Nucleotide stereo-selective reaction modification service
  
  • We use specific biocatalyst enzymes to achieve the introduction of specific modifying groups into nucleotide molecules. The enzyme recognizes and binds a substrate with a specific stereo-configuration so that the reaction occurs only at a specific site and catalyzes a chemical reaction with a specific functional group of the substrate.
  • We use chiral reagents or catalysts to achieve stereoselective modification of nucleotides. These modifiers have specific structural and functional groups that can chemically react with specific positions of the nucleotide and introduce different modifying groups.
• Nucleotide enantio-selective reaction modification service
  
  • We use chiral catalysts to form stable coordination or reaction complexes with the target enantiomers to achieve selective modification of the target enantiomers.
  • We achieve this by selecting compounds with specific chiral structures that have chiral recognition capabilities that allow them to selectively react or bind to specific chiral centers in nucleotides. This results in highly selective modification of the target enantiomer.
  • We use specific enzymes to recognize and bind to specific enantiomers, triggering the corresponding modification reactions.

Fig.2 Classification of methods for stereo- and enantioselective reaction modification of nucleotides. (CD BioGlyco)

Applications

• Nucleotide modification can be used to synthesize nucleotide analogs with specific stereo structures, thereby modulating their biological activities and pharmacological properties.
• Nucleotide modification techniques can be used to design and construct highly sensitive biosensors. These biosensors can be used to detect specific molecules or biological processes and play an important role in areas such as medical diagnostics, environmental monitoring, and food safety.
• Selective reactive modification of nucleotides can also be used to extend nucleic acid technology, such as the synthesis of DNA or RNA molecules with specific stereo structures. These modified nucleic acid molecules can be used for applications in areas such as molecular diagnostics and nanotechnology.

Advantages of Us

• We have a team of professionals who are familiar with the latest developments in nucleotide chemistry and reaction modification.
• We offer custom synthesis program designs based on specific client needs and synthesis goals.
• We will provide timely feedback on the progress of the project, respond positively to the client's feedback, and provide necessary explanations and solutions to ensure client satisfaction with the project.

CD BioGlyco is committed to providing superior, customized solutions to help you make breakthroughs in the field of Nucleotide Modification and Oligonucleotide Modification. Whether it is a stereoselective or enantioselective modification, we will design and optimize the reaction system according to the specific needs of our clients to achieve efficient and accurate modification. If you are interested in our services, please feel free to contact us without delay for more detailed information.