Uses of Uracil Nucleotides

Uridine nucleotides (UMP), also known as monophosphoryl uridine, is an ester composed of phosphate and the nucleoside uridine, which together with cacodylic acid (CMP) forms the pyrimidine nucleotide portion of RNA. The uracil nucleotides play important roles in cell structure, metabolism, energy, and functional regulation. In addition, uracil nucleotides are synthetically active substances that can act as coenzyme components and methyl donors in the body, etc. UMP plays an integral role in intestinal nutrition and promotes the normal development, maturation, improvement, and repair of the intestinal tract. On the other hand, UMP also has a regulatory effect on the body's immune system. It can contribute to the maintenance of cellular and humoral immune responses, and can also relieve some of the immunosuppression. Currently, uracil nucleotides are widely used in food flavoring, infant milk powder, agriculture, and the medical industry, which has great prospects for development.

Fig.1 The chemical structure of uracil nucleotide. (CD BioGlyco)

Uracil Nucleotide Production Service at CD BioGlyco

CD BioGlyco has conducted comprehensive research into the production of uracil nucleotides and has many years of production experience. We have developed various methods for the production of uracil nucleotides as follows:

• Chemical Methods
  Chemical means is a well-established method for the production of uracil nucleotides. In this method, we primarily utilize the phosphorylation reaction of nucleosides. Before phosphorylation, we employ a protection-deprotection mechanism to avoid unwanted side reactions, thereby increasing production efficiency.
• Microbial fermentation
  Microbial fermentation is an environmentally friendly and efficient method. CD BioGlyco offers some production routes:
  • Direct fermentation using bacteria.
  • Fermentation combined with chemical methods.
  • Fermentation combined with enzymatic methods.

The production of uracil nucleotides by microbial fermentation is non-additive, and non-toxic, and ensures that the UMP produced can be used in food, medical or agricultural applications.

In addition to the production services mentioned above, CD BioGlyco also provides isolation and purification services. We provide our clients with ion exchange resins, HPLC, and other technical services to analyze the structure and purity of UMP promptly.

Fig.2 Types of nucleotides and methods of production and analysis. (CD BioGlyco)

Applications

• Uridine nucleotides could be used in the development of food additives.
• Uridine nucleotides could be used in the production of pharmaceutical raw materials and intermediates.
• Uridine nucleotides could be used in research for the production of animal feed.

Advantages

• The production of uracil nucleotides helps to explore their functions such as anti-tumor activity.
• We have a wide range of methods in the production of uracil nucleotides to provide Custom Production Solutions to our clients.
• We have a team of experienced professionals with vast experience in nucleotide production to provide accurate guidance to our clients.

CD BioGlyco has an advanced and systematic platform for analyzing nucleotide production. We provide custom production research solutions to each customer in response to their needs. During the production process according to the client's requirements, we will continue to improve the production route. We are confident in providing our clients with characteristic and efficient uracil nucleotide production solutions. If you are interested in our services, please feel free to contact us.