Adenine Nucleotide Derivative Production Service

Purine Nucleotide Derivatives-an Important Class of Antiviral and Antitumor Drugs

Adenine is a purine derivative that contains two nitrogen-containing rings, which can form double bonds with thymine in the nucleotide structure. It is a nucleotide composed of adenine, ribose, and phosphate, mainly including adenosine monophosphate (AMP), adenosine diphosphate (ADP), and adenosine triphosphate (ATP). Adenine nucleotide derivatives are produced when different chemical unit modifications are introduced into their molecular structure. These chemical modifications can change the properties of compounds, and increase their functions and applications, which play a vital role in exploring biological processes for example gene regulation, protein interaction, signal transduction, and cell metabolism. At present, purine nucleotide derivatives have become an important class of antiviral and antitumor drugs, and a variety of effective derivatives have been marketed for the treatment of HIV, HBV, CMV, and other viral infectious diseases.

Adenine Nucleotide Derivative Production Services at CD BioGlyco

  • Custom Synthesis Services

CD BioGlyco provides professional services for the custom synthesis of adenine nucleotide derivatives. For example, adenine nucleotide standard, derivatives, and analogs that include nitrogen heterocyclic compounds, and thiol compounds.

  • Chemical Modification Services

CD BioGlyco provides mature adenine nucleotide derivative modification services. Introduce different functional or modification units on the adenosine molecule, which can change its properties and functions.

  • Phosphate modification
  • Glycosyl modification
  • Amino ester modification
  • Methylation modification
  • Polymer Modification Services

CD BioGlyco provides synthesized modified adenine nucleotide polymers, such as modifying RNA or DNA strands, to regulate function, stability, and characteristics.

  • Labeling and Probe Preparation Services

CD BioGlyco provides synthesized fluorescent labels, radioactive isotope labels, biotin labels, and other probes for labeling adenosine, which are applied in molecular biology, or radioactivity measurement.

  • Product Purification and Analysis Services

CD BioGlyco purifies and analyzes the synthesized products to ensure high purity, stability, and consistency.

Specialized adenine nucleotide derivative production services.Fig.1 Specialized adenine nucleotide derivative production services. (CD BioGlyco)

Applications

Molecular biology

  • Adenine derivatives may serve as an experimental tool, to analyze the functions, interactions, and metabolic pathways of biomolecules.

Medical imaging

  • Radioisotope labeling of adenine derivatives can be used in nuclear medicine imaging, for example, single photon emission computed tomography (SPECT), and positron emission computed tomography (PET).

Molecular diagnosis

  • The labeling and modification of adenine derivatives have important application value in disease diagnosis, genetic disease screening, and tumor marker detection.

Highlights

  • Flexible customization options: Clients choose different adenine derivatives modifications, labels, or other functional groups according to their research needs.
  • High-quality products: A professional technical team provides high-quality adenine nucleotide derivatives to ensure product purity, stability, and consistency.
  • Technical support and consultation: Provide technical support and professional consultation related to adenine derivatives production services, including experimental design, optimization of modification schemes, and resolution of possible problems.

CD BioGlyco has extensive experience in nucleotide production, and we provide the best adenine nucleotide derivatives production services. Other Nucleotide Derivative Production Services, including Cytosine Nucleotide Derivative Production Service, Guanine Nucleotide Derivative Production Service, Uracil Nucleotide Derivative Production Service, and Thymine Nucleotide Derivative Production Service are also provided. Please feel free to contact us if you want to learn more about nucleotide derivatives production services.

References

  1. Wang, C.; et al. Adenine: an important drug scaffold for the design of antiviral agents. Acta Pharmaceutica Sinica B. 2015, 5(5): 431-441.
  2. Sikk, P.; et al. Ultra performance liquid chromatography analysis of adenine nucleotides and creatine derivatives for kinetic studies. Proceedings of the Estonian Academy of Sciences. 2009, 58(2).
This service is for Research Use Only, not intended for any clinical use.

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