Nucleoside-based Nitrogenous Base Production Service

Overview of Nitrogenous Bases

Bases, derivatives of purines and pyrimidines, also known as nucleobases and nitrogenous bases in biochemistry, are nitrogenous compounds that form nucleosides, which in turn are components of nucleotides. Therefore, monomers such as bases, nucleosides, and nucleotides constitute the basic building blocks of nucleic acids. Nucleobases can form base pairs and stack on top of each other, so they are important components of long-chain helical structures such as ribonucleic acid (RNA) and deoxyribonucleic acid (DNA). There are five common bases found in living organisms, adenine (A), guanine (G), cytosine (C), thymine (T), and uracil (U). Of the five bases, adenine and guanine have a bicyclic structure. The ring system of cytosine, uracil, and thymine is a six-membered heterocycle. They are the basic units that make up the genetic code, of which the bases A, G, C, and T are found in DNA, and A, G, C, and U are found in RNA.

Fig.1 (a) Structure of five natural nucleic acid bases; (b) structure model of B-DNA; (c) DNA base pairing through hydrogen bonds. (Li, et al., 2021)

Nucleoside-based Nitrogenous Base Production Service at CD BioGlyco

The five common bases in living organisms play a very important role in the organism itself, and they have great prospects for development in the fields of medicine, agriculture, and so on. Therefore, it is necessary to develop comprehensive base production services. At CD BioGlyco, we provide a variety of methods for the production of Adenine, Guanine, Cytosine, Uracil, and Thymine.

• Chemical method
  For purine-like bases, they consist of a system of densely packed pyrimidine-imidazole rings with conjugated double bonds. Depending on their chemical structure, we offer several routes of chemical synthesis:
  
  • Synthesis of purines from pyrimidine derivatives.
  • Synthesis of purines from acid derivatives under photocatalysis.
  
  The yields of purines prepared by these two routes reach more than 70% and are highly efficient and environmentally friendly. For pyrimidine bases, the production route is mainly catalyzed by hydrogenation reduction or cyclization reaction to prepare the target product.
• Biological method
  At CD BioGlyco, we produce purines or pyrimidines in large quantities by direct extraction. This method is environmentally friendly and easy to operate, making it an excellent choice for the production of bases.

Fig.2 Two production methods for nitrogen-containing bases. (CD BioGlyco)

Applications

• Nitrogen-containing bases are used in antibiotic production research.
• Nitrogen-containing bases are used in cancer treatment research.
• Nitrogen-containing bases are used in developmental studies of genetics.
• The production of bases contributes to the study of the structure and physiological function of nucleosides.
• The production of bases helps to further extend the range of applications of bases.

CD BioGlyco has a professional research team that customizes different production solutions according to the different research needs of our clients. We have professional laboratory equipment and experienced researchers to provide you with custom base production services.

Customers can contact our staff directly and we will reply promptly. If you are interested in our services, please feel free to contact us for more details.