Properties of Carboxylated Polysaccharides

Carboxylated polysaccharides are water-dispersible and have received a lot of attention from scientists because they can be used as drug carriers. Currently, polysaccharides containing carboxylic groups such as hyaluronic acid, xanthan exemplify, and gellan have been prepared in large quantities and are widely used in many fields such as food, cosmetics, medicine, and pharmaceuticals. These products can be recovered from natural sources and are biodegradable and biocompatible, which makes them an important alternative to conventional synthetic polymers such as polyolefinic and polyacrylic products.

In carboxylic groups-containing polysaccharides, the presence of hydrogen bonds that can lead to the formation of secondary structures and the high reactivity of the carboxylic groups make it challenging to obtain selectively modified derivatives. Notably, it is interesting to obtain carboxylated polysaccharides in their derivative forms thus affecting their biofunctional properties. The properties of these polysaccharides such as bioavailability, biodegradability, ionic strength, and thickening/gelling properties can be extensively varied by introducing chemical modifications at, for example, hydroxyl groups.

Biodegradable Polysaccharide Carboxylation Services at CD BioGlyco

Our researchers are dedicated to providing our clients with Biodegradable Polysaccharide Derivatization services to prepare chemically modified polysaccharides with the desired characteristics. For example, the carboxylation of pullulan polysaccharides has the potential to improve their flexibility, solubility, and adhesion. Carboxylation of chitosan has the potential to improve its water solubility and to yield new polysaccharide derivatives with excellent physicochemical properties and biological activities. Our carboxylation services can be applied to a wide range of compounds, including dextran, starch, cellulose, and other polysaccharides. Our services include, but are not limited to:

• Carboxylation of polysaccharides
  We engineer carboxyl groups onto the natural polysaccharide backbone to provide a flexible, water-dispersible, and biocompatible material. We offer different oxidation methods such as the use of hypochlorite, sodium periodate, or ozone to form aldehyde structures which are then further oxidized in situ to carboxylate groups using oxidants. We offer customized synthesis protocols to suit our customer's specific needs and control the percentage of carboxyl groups incorporated, the attachment position, and molecular weight by controlling the nature, amount, and conditions of oxidation or hydrolysis.
• Characterization of carboxylated polysaccharides
  We offer Fourier transform infrared spectroscopy (FTIR), environmental scanning electron microscope (ESEM), nuclear magnetic resonance (NMR) spectroscopy, and titration to help our clients characterize the structure of these materials and analyze the carboxyl content.

Applications

• Preparation of hydrogels
• Development of protein stabilizing agents
• Development of drug delivery carriers

CD BioGlyco has professional knowledge and accumulated extensive experience in the field of chemical synthesis and structural characterization. We provide clients with polysaccharide carboxylation services to obtain Polysaccharide-based Biodegradable Materials with specific properties.

If you are interested in our business, please feel free to contact us for more details.