Biodegradable Polysaccharide Grafting

CD BioGlyco is dedicated to exploring various strategies for the design and synthesis of controllable polymer-grafted polysaccharides to produce polymer-grafted polysaccharides with satisfactory properties. Our rational experimental protocols help our clients to effectively improve the properties of polysaccharides and to achieve the multi-functionalization of polysaccharides for extended biomedical applications.

Modification of Polysaccharides via Polymer Grafts

To impart polysaccharides with more functionalities, researchers have explored various modification methods to improve the physicochemical and biochemical functionality of polysaccharides and effectively manipulate the desired functions. Conventional modification methods typically consume large amounts of amino, carboxyl, or hydroxyl groups of polysaccharides, resulting in disruption of the structural and functional integrity of polysaccharides. However, the grafting of polysaccharides with functional polymers is a strategy that requires only a limited number of reactive sites for the polysaccharide to be occupied, thus maximizing the structural integrity.

Modern polymerization methods such as living radical polymerization (LRP) and ring-opening polymerization (ROP) offer many advantages in the preparation of well-defined polymer grafts, offering the possibility of developing polymers with simple reaction conditions, unrestrained solvents, a range of functional monomers, and structural flexibility. Graft modification of polymers has now become a simple and effective way to expand the field of application of polysaccharides and improve the properties of polymeric materials.

Fig.1 (a) Structural illustration of A-CD-PGEA. (b) Acid-lability of A-CD-PGEA characterized by GPC and AFM. (Hu, et al., 2017)

Biodegradable Polysaccharide Grafting Services at CD BioGlyco

We provide our clients with rational methods for the synthesis of polymer-grafted polysaccharides to help them improve the performance of polysaccharides. Our services of Modification of Biodegradable Polysaccharides may extend the use of polysaccharides in biomedical applications, including gene/drug delivery, bioimaging, and multifunctional applications. CD BioGlyco offers a wide range of polymers such as poly(2-(dimethylamino)ethyl methacrylate)) (PDMAEMA) and poly(glycidyl methacrylate) (PGMA) grafts to modify a variety of polysaccharides such as starch, pectin, cellulose, hyaluronic acid, rhamnose, xylan, chitosan, etc. Our services include, but are not limited to:

• Development of polymer-grafted polysaccharides by atom transfer radical polymerization (ATRP)
  We use LRP to chemically modify polysaccharides to achieve functionalized polysaccharides with multiple grafts.
  
  • Introduction of cationic components for gene delivery.
  • Introduction of PEGylated and zwitterionic moieties for shielding effects.
  • Introduction of functionalized substances for bioimaging applications and bioresponsive drug release applications.
• Development of biodegradable- polymer-grafted polysaccharides by ROP
  We help clients prepare biodegradable polymer-grafted polysaccharides, mainly poly(amino acid) and polyester via the introduction of biodegradable polymers through "grafting from" and "grafting onto" methods.
  
  • Synthesis of poly(amino acid)-grafted polysaccharides with advanced structures (including linear, comb-shaped, and star-shaped, copolymers) via direct ROP from polysaccharides.
  • Synthesis of biodegradable polyester graft polysaccharides to obtain new amphiphilic materials for drug delivery.
• Development of polysaccharide-based assemblies with supramolecular structures
  We have established a variety of assembly technologies using non-covalent interactions to help our clients prepare different types of polysaccharide-based assemblies with multiple biological applications.

CD BioGlyco focuses on the recent progress in synthetic methodologies of versatile types of polymer-grafted polysaccharides to help clients prepare Polysaccharide-based Biodegradable Materials.

If you are interested in our business, please feel free to contact us for more details.