At CD BioGlyco, our carbohydrate-based nanoparticles at GlycoNano™ Platform are nano-sized materials derived from carbohydrates, valued for their biocompatibility, biodegradability, and capacity to interact with biological systems via non-covalent interactions. These nanoparticles are extensively applied in drug delivery, tissue engineering, imaging, and immunotherapy due to their ability to encapsulate hydrophilic and hydrophobic molecules, provide controlled release, and enhance stability.
Carbohydrate-based nanoparticles can be produced using techniques such as chemical synthesis, enzymatic modification, and self-assembly driven by hydrogen bonding or hydrophobic interactions. These methods enable the creation of monosaccharide-based and polysaccharide-modified nanoparticles with tailored properties for biomedical applications.
Mono- and disaccharides are chemically modified to form amphiphilic structures like micelles and vesicles.
Enzymes produce well-defined carbohydrate structures with high regioselectivity.
Such as hydrogen bonding and hydrophobic interactions drive the formation of carbohydrate-based nanoparticles.
Naturally derived polysaccharides are processed and modified chemically or physically for nanoparticle formation.
Cyclodextrin-based nanofibers are created via electrospinning for drug encapsulation and delivery.
Based on the Glyconanoparticle Development Service, our carbohydrate-based nanoparticle production service offers tailored solutions for creating advanced carbohydrate-derived nanoparticles. This service includes the monosaccharide-based nanoparticle production service, focusing on the precise synthesis and assembly of nanoparticles from simple sugars, and the polysaccharides-modified nanoparticle production service, which utilizes natural or modified polysaccharides to produce functional nanoparticles with enhanced stability and application-specific properties.
CD BioGlyco offers various analytical services essential for characterizing carbohydrate-based nanoparticles, ensuring their quality and functionality through precise and reliable methods.
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Glyconanoparticle Physicochemical Property Characterization Service |
Glyconanoparticle Molecule Interaction Analysis Service | |
Glyconanoparticle Characterization Service |
Glyconanoparticle development encompasses diverse techniques, including hydrogen bonding, coulombic interactions, hydrophobic effects, CuAAC, amide coupling, nucleophilic substitution, and photocoupling, enabling tailored solutions for advanced biomedical applications.
Carbohydrate nanoparticles encapsulate hydrophilic and hydrophobic drugs, ensuring targeted and controlled release.
01Carbohydrate-based hydrogels and scaffolds support cell growth and tissue regeneration.
02Carbohydrate nanoparticle materials can serve as contrast agents or carriers for imaging agents.
03Carbohydrate assemblies, such as glycopeptide nanostructures, are used to modulate immune responses or deliver vaccines.
04Carbohydrate-based nanoparticles target specific carbohydrate-protein interactions to inhibit bacterial or viral infections.
05Technology: Surface functionalization, Self-assembly, Thiol–ene reaction, Click chemistry, Polymerization
Journal: Chemical Society Reviews
IF: 40.4
Published: 2015
Results: The study explores carbohydrate-based nanocarriers' potential in biomedical applications, focusing on functionalization and construction. Key findings include the ability of carbohydrates to improve biocompatibility, stability, biodegradability, and targeting efficiency in drug delivery systems. Surface modification with specific saccharides enhances receptor-mediated uptake, reduces nonspecific cellular interactions, and enables payload release through enzymatic degradation. These properties make carbohydrate-functionalized nanocarriers effective for targeted drug delivery, imaging, and therapeutic applications.
Fig.1 Relationship between different carbohydrates. (Kang, et al., 2015)
At CD BioGlyco, our carbohydrate-based nanoparticle production service uses technologies, for example, chemical synthesis, enzymatic modification, and self-assembly, to create precisely engineered nanoparticles. Our custom options, like monosaccharide-based and polysaccharide-modified nanoparticles, this service provide solutions to meet the complex demands of modern research and therapeutic development. Please do not hesitate to contact us to explore how we support your research and needs.
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