Polysaccharides-modified nanoparticles are engineered using natural polysaccharides, offering exceptional biocompatibility, biodegradability, and low toxicity. These nanoparticles are widely applied in drug delivery, tissue engineering, diagnostic imaging, and sustainable industrial processes. Their ability to encapsulate bioactive substances, target specific tissues, and enhance stability makes them versatile tools in various fields. Synthesis Methods include ionic/covalent crosslinking, self-assembly, and polyelectrolyte complexation, enabling controlled size and morphology.
Fig.1 Overview of polysaccharide NP formation and their applications. (Plucinski, et al., 2021)
Our GlycoNano™ Platform offers advanced Glyconanoparticle Development Services and Carbohydrate-based Nanoparticle Production Services. By integrating carbohydrates into nanoparticle structures, our systems are not only biocompatible and biodegradable but also capable of selectively targeting specific cells and tissues.
Fig.2 Chemical structures of polysaccharides. (Plucinski, et al., 2021)
CD BioGlyco offers an extensive polysaccharides-modified nanoparticles production service through our GlycoNano™ Platform, catering to diverse research and industrial needs. These services include customized solutions, such as pH-sensitive Ganoderma polysaccharide nanoparticles, cholesterol-modified pullulan nanoparticles, and dextran-polyacrylic acid nanoparticles, ensuring tailored approaches to meet specific scientific challenges.
| Ganoderma Polysaccharides-modified Bismuth Sulfide Nanoparticle Production | ||
| ASP-PLGA NPs Production | ||
| Acetylsalicylic Acid/Aminoglycan Complex Nanoparticle Production | ||
| Stearic Acid-modified Pullulan Polysaccharide Nanoparticle Production | ||
| Fucoidan Self-Assembly Nanoparticle Production | ||
| Cholesterol-modified Pullulan Polysaccharide Self-Assembled Nanoparticle Production | ||
| Ganoderma Lucidum Polysaccharide-histidine Conugated pH-Sensitive Nanoparticle Production | ||
| pH/Redox Response of Ganoderma Lucidum Polysaccharide Conjugated Nanoparticle Production | ||
| pH-Responsive Ganoderma Polysaccharides-Phenylborate-Methotrexate Conjugated Nanoparticle Production | ||
| Alginate-modified Nanoparticle Production | ||
| Modified Sodium Alginate Activated SiO2 Nanoparticles | Alginate Nanoparticles | Galactose-modified Alginate Nanoparticles (Dox/Ha-Gal) |
| Biparental Hydroxypropyl-β-Cyclodextrin Nanoparticles | ||
| Chitosan-modified Glyconanoparticle Production | ||
| Chitosan conjugated Ovalbumin Nanoparticles (Ova-Chitosan) | Methyl Chitosan Nanoparticles | Carboxymethyl Chitosan Nanoparticles |
| Novel Chitosan Grafted Copolymer Nanoparticles | Amphiphilic Fluralin/Carboxymethyl Chitosan Nanoparticles | Water-Soluble Chitosan Nanoparticles |
| Salicylate Chitosan Nanoparticles | Chitosan Fluorescent Nanoparticles | Chitosan-Phospholipid Self-Assembly Nanoparticles |
| Folic Acid Conjugates Chitosan Nanoparticles | Bsa Loading Properties of Water-Soluble Chitosan Nanoparticles | Emodin/Berberine-Chitosan Double Nanoparticles |
| Oleanolic Acid Grafted onto Chitosan Nanoparticles | Pegyl-Chitosan-Curcumin Polymer-Nanoparticles | Glycyrrhizate-modified Chitosan/Carboxylated Chitosan Composite Nanoparticles |
| Chitosan Nanoparticles-modified By Quaternary Amine Salt | Self-Assembled Chitosan Nanoparticles | Chitosan Grafted Copolymer Nanoparticles |
| Temperature Sensitive Chitosan Based Polyelectrolyte Nanoparticles | Cholesterylated Chitosan Nanocarriers | Glycyrrhetinic Acid-modified Chitosan Nanoparticles |
| Hydrophobic Modification of Magnetic Chitosan Nanoparticles | Chitosan A Mesoporous Silica Nanoparticles | Trimethylated Chitosan Oobumin Nanoparticles |
| Chitosan Grafted Polymer Nanoparticles | Chitosan-mesoporous Siica Nanoparticles | |
| Dextran-polyacrylic Acid Nanoparticle Production | ||
| Hyaluronic Acid-modified Nanoparticle Production | ||
| Hyaluronic Acid-modified Dexamethasone Core-Shell Nanoparticles | Hyaluronic Acid-modified Prussian Blue Nanoparticles | Hyaluronic Acid Nanoparticle Polyelectrolyte Complex |
| Hyaluronic Acid-modified pH-Sensitive Core-Shell Nanoparticles | Hyaluronic Acid-modified Albumin Nanoparticles | |
To ensure the reliability and performance of polysaccharides-modified nanoparticles, several analytical methods are used.
Dynamic Light Scattering
Measures particle size and size distribution.
Transmission Electron Microscopy
Analyzes morphology and surface structure.
Zeta Potential Analysis
Assesses surface charge and stability.
High-Performance Liquid Chromatography
Evaluates drug encapsulation and release profiles.
Fourier Transform Infrared Spectroscopy
Confirms chemical modifications.
Technology: Scanning electron microscopy, Transmission electron microscopy, Atomic force microscopy, Nanoparticle tracking analysis, Dynamic light scattering, Fourier transform infrared spectroscopy, X-ray diffraction
Journal: Journal of Materials Chemistry B
IF: 6.1
Published: 2021
Results: This review delves into the world of polysaccharide nanoparticles (polysaccharide NPs), emphasizing their unique properties like biocompatibility, biodegradability, renewable origin, and easy modification, making them ideal building blocks for NP fabrication. It introduces various common polysaccharides such as chitosan, cellulose, starch, hyaluronic acid, dextran, pullulan, alginate, and carrageenan, discussing their properties and applications in NP formation. It also explores multiple strategies for synthesizing polysaccharide NPs, including nanoprecipitation, complex coacervation, emulsion-based methods, and other techniques like desolvation, dialysis, ionic gelation, and spray drying.
Fig.3 Avenues for the preparation of polysaccharide NPs. (Plucinski, et al., 2021)
At CD BioGlyco, we use advanced techniques such as ionic crosslinking, covalent modification, and self-assembly, we produce nanoparticles with exceptional biocompatibility, stability, and targeting capabilities. Our offerings include specialized products like Ganoderma polysaccharides-modified bismuth sulfide nanoparticles, chitosan-modified nanoparticles, and hyaluronic acid-modified nanoparticles. Contact us today to explore how our polysaccharides-modified nanoparticlecan help advance your research.
Reference
