As an emerging nanomaterial, glyconanoparticle provides new ideas and methods for solving many disease problems. Sugar chains, as important recognition molecules on the cell surface, give glyconanoparticle specific biological functions, giving it unique advantages in targeted drug delivery, bioimaging, tissue engineering, etc. By loading drugs or probe molecules onto the surface of glyconanoparticle, accurate disease diagnosis and treatment are achieved, the treatment effect is improved, and side effects are reduced. In addition, glyconanoparticle is also used to construct biomaterials with good biocompatibility to promote tissue regeneration and repair. CD BioGlyco has developed an advanced GlycoNano™ Platform, which aims to develop new glyconanomaterial by integrating multidisciplinary knowledge such as sugar chemistry, nanotechnology, and biomedicine. The glyconanoparticle is applied to the biomedical field to solve major challenges facing current medical care, such as cancer and neurodegenerative diseases.
With our deep experience in sugar chemistry and nanotechnology, we have established a complete Glyconanoparticle Preparation System. By fine-tuning the synthesis parameters, we customize glyconanoparticles that meet your requirements in terms of particle size, morphology, surface functionalization, etc. Our technologies for glyconanoparticle development include but are not limited to:
We provide a simple and efficient glyconanoparticle preparation method. Through self-assembly based on the hydrophobic effect, we construct glyconanoparticles with good stability and biocompatibility to meet your various needs in the fields of biomedicine, materials science, etc.
Using the CuAAC reaction, sugar molecules and nanoparticles are efficiently connected to construct glyconanoparticles with customized functions to meet your various needs in the fields of biomedicine, materials science, etc. This method has mild reaction conditions, high yield, and few side reactions.
Sugar chains are connected to nanomaterials through peptide bonds. This natural amide bond not only gives glyconanoparticle excellent biocompatibility, but also achieves precise control of sugar chain density and orientation by precisely regulating the amino acid sequence, providing unlimited possibilities for biomedical research.
The abundant hydroxyl groups on sugar molecules are used as nucleophiles to undergo nucleophilic substitution reactions with leaving groups on the surface of nanoparticles. This reaction condition is mild and highly selective, achieving precise modification of sugar chains on the surface of nanoparticles.
We prepare glyconanoparticles with diverse structures and rich functions by selecting different photosensitive groups and reaction systems. Whether it is for drug delivery, bioimaging or tissue engineering, we tailor the most suitable glyconanoparticles for you.
With advanced technology, we provide clients with unparalleled glyconanoparticle production services. Our service process is as follows:
We customize the synthesis of sugar chains with various complex structures for you, including natural oligosaccharides, glycoconjugates, and artificial sugar chains with special functions. We use strategies such as chemical synthesis, enzymatic synthesis, and combinatorial synthesis to meet the needs of different clients. Through strict quality control, the purity and structural accuracy of the synthesized products are ensured.
We provide flexible nanocarrier options. Through chemical bonding, physical adsorption, self-assembly, and other modification methods, various types of sugar chains are accurately modified to the surface of nanocarriers, achieving precise regulation of the surface properties of nanomaterials to meet your application needs in different fields.
To ensure the quality and performance of glyconanoparticles, high-resolution technologies such as nuclear magnetic resonance (NMR) and mass spectrometry (MS) are used to accurately characterize the structure and purity of sugar chains. At the same time, we also use imaging technologies such as transmission electron microscopy to visually observe the morphology and size distribution of glyconanoparticles. The combination of these advanced technologies enables a full range of characterization of glyconanoparticles.
Glyconanoparticles are given more diverse biological functions by introducing functional molecules such as fluorescent molecules and drug molecules. For example, fluorescent molecules are introduced to achieve fluorescent imaging of cells, which is used to study cell uptake, localization, and metabolic processes. Drug molecules are introduced to construct targeted drug delivery systems, thereby achieving precise treatment of diseases such as tumors.
DOI: 10.3390/nano11051162
Journal: Nanomaterials
Published: 2021
IF: 4.4
Results: The authors used nanoprecipitation to self-assemble two amphiphilic glycopolymers in different ratios to obtain polystyrene-block-maltoheptaose copolymer (PS-b-MH) and polystyrene-block-β-cyclodextrin copolymer (PS-b-βCD). Their spherical morphology and nanosize were characterized by dynamic light scattering, scanning, and transmission electron microscopy. In addition, the obtained glyconanoparticles exhibited classical electroactivity by post-functionalization with water-soluble redox compounds using the CD inclusion property. In summary, the regulation of the β-CD surface density on the glyconanoparticle shell provides an attractive method for the preparation of glyconanoparticles with different electroactive properties.
Fig.1 Strategy for functionalized glyconanoparticles of multifunctional redox platform. (Carrière, et al., 2021)
CD BioGlyco has many years of experience in glycobiology and nanomaterials research and development, providing you with high-quality and efficient glyconanoparticle development services. If you need glyconanoparticles, please feel free to contact us and we will tailor the best solution for you.
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