Magnetic nanoparticles, controllable by magnetic fields, consist of a core formed by magnetic materials like iron, nickel, and cobalt, encased in a functional chemical coating. To elevate their performance at the molecular and cellular levels, surface modifications are employed to enhance dispersion, surface activity, and biocompatibility. These coatings can comprise various carbohydrates, including mannose, galactose, fucose, sialic acid, lactose, dextran, cyclodextrin, and starch. CD BioGlyco's GlycoNano™ Platform provides customized development and production of magnetic glyconanoparticles that integrate the controllable properties of magnetic materials with the biocompatibility and specificity of carbohydrate molecules. The surface chemistry of these magnetic glyconanoparticles is meticulously modulated to refine their physicochemical characteristics, enabling their deployment in diverse fields.
Our magnetic glyconanoparticle production service has been at the forefront of innovation, leveraging the extensive research advancements of the past decade to deliver high-quality nanoparticles tailored to your specific needs. We employ a variety of sophisticated synthetic methods to produce magnetic nanoparticles with precisely controlled sizes, morphologies, stabilities, and biocompatibilities.
Each method is meticulously chosen to ensure that the resulting magnetic glyconanoparticle meets the exacting standards required for your applications. We often synthesize magnetic glyconanoparticles using a co-precipitation technique involving iron (II) and iron (III) chloride salts in a basic environment. Stabilizers such as lactobionic acid, d-gluconic acid, and Ficoll are used to ensure stability and prevent agglomeration of the nanoparticles.
We dissolve the iron salts in deoxygenated water and purge the solution with dry nitrogen to remove any dissolved oxygen that could interfere with the synthesis process.
Add the chosen stabilizer (lactobionic acid, d-gluconic acid, or Ficoll) to the iron salt solution to aid in the stabilization of the nanoparticles during formation.
Filter the reaction mixture through a 0.45 µm nylon filter to remove impurities and then degas the mixture by purging with dry nitrogen for an additional period to ensure an oxygen-free environment.
We heat the filtered and degassed mixture in an oil bath at 75°C. After heating for a period, we add ammonium hydroxide to the mixture, causing the co-precipitation of the iron salts, indicated by a change in the solution's color from transparent yellow to opaque black. The mixture is stirred overnight to allow for complete nucleation and growth of the magnetite nanoparticles.
We isolate the resulting nanoparticles by centrifuging at high speed, removing the supernatant, and resuspending the pellet in distilled water. We repeat this washing step to ensure purity. We sonicate the resuspended nanoparticles in a water bath to disperse any aggregates and facilitate uniform size distribution.
We characterize the synthesized magnetic glyconanoparticles using Dynamic Light Scattering (DLS) to determine size distribution and zeta potential, and transmission electron microscopy (TEM) to visualize their morphology and size.
Through these processes, we offer a comprehensive range of tailored magnetic nanoparticles functionalized with various carbohydrate moieties, catering to diverse biomedical applications.
Fucose-magnetic nanoparticles, offered through our advanced technologies, are surface-modified with fucose, a sugar common in Lewis blood group antigens involved in various immune responses. These particles are used in immunological studies, targeted drug delivery, and biosensor development.
Our research team provides nanoparticles with sialic acid coatings, which interact with sialic acid-binding proteins and receptors found on cell surfaces. Applications include cell sorting, targeted drug delivery to cells expressing sialic acid receptors, and serving as ligands in biomedical research.
CD BioGlyco creates particles coated with lactose, a disaccharide known for its stability and interaction with lactose-binding proteins. This makes them suitable for enzyme immobilization, biosensor development and targeted drug delivery to cells expressing lactose receptors.
The dextran-magnetic nanoparticle production service offers nanoparticles covered with dextran, a polysaccharide renowned for its biocompatibility. These nanoparticles are used in targeted drug delivery, enzyme immobilization, and as carriers for various therapeutic agents.
We produce particles functionalized with cyclodextrin, a cyclic oligosaccharide that forms inclusion complexes, enhancing the stability and solubility of enclosed molecules. Applications include drug delivery systems, and carriers for poorly soluble drugs.
We offer a starch-magnetic nanoparticle production service that provides nanoparticles coated with starch, a polysaccharide known for its biocompatibility and biodegradability. These particles are utilized in tissue engineering, and drug delivery, and serve as scaffolds for cell growth and tissue repair.
DOI: 10.3389/fmats.2019.00179
Journal: Frontiers in Materials
Published: 2019
IF: 2.6
Result: This passage reviews the significant advancements in the field of magnetic nanoparticles, particularly iron oxide nanoparticles, as versatile "theranostic" agents. It highlights the unprecedented increase in research attention over the past two decades, emphasizing their vital roles in imaging, drug delivery, controlled release, hyperthermia, atherosclerosis diagnosis, and prostate cancer treatment. The review discusses the substantial progress made in controlling the size and shape of these nanoparticles through various synthesis methods, such as precipitation, co-precipitation, thermal decomposition, hydrothermal synthesis, microemulsion synthesis, and plant-mediated synthesis. It also addresses the critical challenge of protecting these nanomaterials against corrosion to ensure their stability and functionality in catalysis, biology, and medicine. Finally, the combined applications of imaging and drug delivery in theranostics are explored, along with considerations of the potential toxicity of iron oxide magnetic nanoparticles.
CD BioGlyco stands out for its bespoke magnetic glyconanoparticle production, harnessing advanced platforms to develop a diverse array of Glyconanoparticles. Our rigorous synthetic protocols and exhaustive characterization ensure the delivery of high-quality, functionalized nanoparticles, meeting the intricate demands of various biomedical research and applications. If you are interested in our diverse array of sugar-coated nanoparticles, contact us!
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