Gold glyconanoparticles (GNPs) are nanoscale materials that combine the optical and chemical properties of gold with the biological functionality of carbohydrates. These nanoparticles are versatile, with precise control over size, surface chemistry, and functionality, typically between 1 and 100 nm. Carbohydrate functionalization allows GNPs to target specific biological molecules, making them useful for drug delivery, bioimaging, biosensing, and therapeutic development. GNPs offer stability, biocompatibility, and tunable surface modifications.
Fig.1 SEM images of (a) S-2, (b) R-2, and (c) St-2 glyco-gold nanoparticles. (Sangabathuni, et al., 2017)
At CD BioGlyco, through our GlycoNano™ Platform, offers a comprehensive Glyconanoparticle Development Service, enabling the production of high-quality glyco-functionalized gold nanoparticles for diverse applications. Our service includes monosaccharide-gold nanoparticle production service and polysaccharide-gold nanoparticle production service, providing tailored solutions to meet specific research and industrial needs.
Monosaccharide-based nanoparticles provide high specificity and precise targeting due to their ability to mimic natural carbohydrate-receptor interactions, making them ideal for the development of drug delivery, diagnostics, and imaging. Polysaccharide-based nanoparticles offer enhanced biocompatibility, stability, and multifunctionality, supporting applications in cancer therapy research, antimicrobial research, and sustained drug release research. You can explore our Techniques for Glyconanoparticle Development to study more details about our services.
Our polysaccharide-gold nanoparticle production service specializes in creating gold nanoparticles functionalized with polysaccharides such as mannose, chitosan, heparin, dextran, cyclodextrin, hyaluronic acid, and PEG. These nanoparticles are tailored for diverse applications in drug delivery, cancer therapy, diagnostics, imaging, and glycoscience research. With options like cyclodextrin-coupled nanoparticles for drug encapsulation, PEG-modified nanoparticles for targeted imaging, and mannose- or heparin-based nanoparticles for therapeutic studies, the service ensures high biocompatibility, stability, and application-specific functionality to advance research and innovation.
Characterization Analysis is essential for evaluating the quality, functionality, and biocompatibility of glyconanoparticles, encompassing methods for physicochemical analysis, molecular interaction studies, surface chemistry assessment, and biological validation.
Biomedical Research
Therapeutic Development
Analytical Chemistry
Technology: Click chemistry, Thiol coupling, Dynamic light scattering, Transmission electron microscopy, Surface-enhanced Raman spectroscopy, MALDI-TOF Mass spectrometry
Journal: Frontiers in Chemistry
IF: 3.8
Published: 2021
Results: The study examines the advancements and applications of glyconanoparticles and glyco-functionalized quantum dots in detecting lectins, viruses, bacteria, and cancer cells. Carbohydrate-coated nanoparticles enhance interaction stability, enable targeted diagnostics, and improve imaging precision. Key findings reveal that glyconanoparticles, particularly gold-based ones, offer high sensitivity for detecting pathogens and biomarkers, exhibit strong selectivity in lectin and carbohydrate-binding interactions, and show therapeutic potential in inhibiting bacterial growth, reducing cancer cell viability, and blocking viral entry.
Fig.2 Glyconanoparticle-based assays for the detection of carbohydrate-binding targets. (Hernando, et al., 2021)
At CD BioGlyco, our gold glyconanoparticle production service provides solutions for providing highly functionalized gold nanoparticles. With monosaccharide-based and polysaccharide-based nanoparticle production services, our products have precise targeting, superior biocompatibility, and enhanced stability to meet the needs of your research goals. Please do not hesitate to contact us, Let us help you advance your innovations with our reliable and high-quality products.
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