Monosaccharide-Gold Nanoparticle Production Service

Overview of Monosaccharide-Gold Nanoparticles

Schematic illustration of the reversible regulation of the GOx-like catalytic activity of AuNPs by G-quadruplex DNA nanomachines. (Zhou, et al., 2015)

Monosaccharide-gold nanoparticles are gold nanoparticles functionalized with monosaccharides. These nanoparticles combine the unique optical and chemical properties of gold with the biological specificity of carbohydrates, enabling precise targeting of receptors and biological molecules. Based on our Glyconanoparticle Development, we help our clients with their research.

Our monosaccharide-gold nanoparticle production service provides advanced solutions under the GlycoNano™ Platform, developing gold nanoparticles functionalized with monosaccharides. By integrating carbohydrates like glucose, galactose, and mannose into gold nanoparticle structures, our systems achieve excellent biocompatibility, stability, and the ability to selectively target specific cells and tissues. These nanoparticles are produced by techniques such as chemical conjugation, thiol coupling, and click chemistry, ensuring precise functionalization and robust stability.

Image of glucose. (CD BioGlyco) Glucose-gold nanoparticles

Glucose-modified gold nanoparticles
Glucose & peptide modified gold nanoparticles

Image of glucose. (CD BioGlyco) Galactose-gold nanoparticles

Image of glucose. (CD BioGlyco) Mannose-gold nanoparticles

Image of glucose. (CD BioGlyco) Lactose-gold nanoparticles

Image of glucose. (CD BioGlyco) Maltose-gold nanoparticles

Glyconanoparticle Characterization Service for Monosaccharide-Gold Nanoparticles

Physicochemical Characterization

Polysaccharides-modified nanoparticles require a comprehensive analysis of their physicochemical properties to ensure optimal performance in their applications.

Molecular Interaction Studies

Molecular interaction studies focus on the binding behavior and specificity of monosaccharide-gold nanoparticles.

Biological Validation

Biological validation evaluates the biocompatibility and cellular behavior of monosaccharide-gold nanoparticles.

Spectroscopy and Fluorescence

Spectroscopy and fluorescence techniques are crucial for confirming functionalization and enhancing biosensing applications.

Applications

These nanoparticles can target the delivery of therapeutics to specific cells or tissues and can be used for the development of drug discovery.
These nanoparticles can be used for detecting pathogens, and biomarkers, and studying carbohydrate-protein interactions with high sensitivity.
Their optical properties make them ideal for imaging techniques.
Functionalized nanoparticles can be used to support vaccine development and anti-cancer therapy development.

Advantages

The monosaccharides enable precise targeting of specific receptors, such as lectins or cell-surface proteins.
The nanoparticles exhibit excellent compatibility with biological systems, ensuring minimal toxicity.
Gold nanoparticles are highly stable under various conditions, making them reliable for long-term use.
Custom functionalization allows these nanoparticles to meet a wide range of research and therapeutic needs.

Frequently Asked Questions

What monosaccharides can be functionalized on gold nanoparticles through this service?
Our monosaccharide-gold nanoparticle production service provides nanoparticles functionalized with a variety of monosaccharides, including glucose, galactose, mannose, lactose, and maltose.
How are the quality and performance of monosaccharide-gold nanoparticles ensured?
We use advanced characterization techniques such as dynamic light scattering, transmission electron microscopy, UV-Vis spectroscopy, and surface plasmon resonance to verify nanoparticle size, morphology, functionalization, and interaction efficiency, ensuring high-quality and reliable performance.

Publication

Technology: UV-Vis spectroscopy, Dynamic light scattering, Transmission electron microscopy, Flow cytometry, Live/dead assays, Cholesterol depletion with methyl-β-cyclodextrins

Journal: Materials Today Bio

IF: 8.7

Published: 2024

Results: This study explores the effects of monosaccharide-coated gold nanoparticles (sAuNPs) on dendritic cells (DCs), focusing on their cellular uptake, intracellular trafficking, and immune modulation. By functionalizing 16 nm spherical gold nanoparticles with mannose, galactose, or fucose, the researchers demonstrated that the type of monosaccharide coating influences both the uptake efficiency and the intracellular localization of the nanoparticles. Fucose-coated nanoparticles exhibited the highest uptake and preferential localization in lysosomes, while mannose-coated nanoparticles favored endosomal localization, highlighting the role of C-type lectin receptors in receptor-mediated endocytosis. These findings underscore the potential of glycan-functionalized gold nanoparticles as targeted delivery systems in vaccine development and immunotherapy, offering valuable insights into the design of advanced antigen delivery platforms.

Fig.3 Avenues for the preparation of polysaccharide NPs: (a) covalent crosslinking, (b) ionic crosslinking, (c) complexation of oppositely charged polysaccharides, (d) self-assembly of hydrophobically (blue sphere) modified polysaccharides and (e) polysaccharide–drug (green sphere) conjugate. Fig.1 Schematic of the functionalization of gold nanoparticles with glycan-functionalized fluorescent polymers. (Alobaid, et al., 2024)

At CD BioGlyco, our monosaccharide-gold nanoparticle production service provides advanced, customizable solutions for producing high-quality gold nanoparticles functionalized with monosaccharides. Please feel free to contact us today to explore how our products can help advance your research.

References

Zhou, P.; et al. Reversible regulation of catalytic activity of gold nanoparticles with DNA nanomachines. Scientific Reports. 2015, 5(1): 14402.
Alobaid, M.A.; et al. Monosaccharide coating modulate the intracellular trafficking of gold nanoparticles in dendritic cells. Materials Today Bio. 2024: 101371.

This service is for Research Use Only, not intended for any clinical use.