CD BioGlyco develops a wide range of Carbohydrate-based Biodegradable Materials for biomedical, industrial, and food applications based on advanced technology and equipment. Disaccharides have good biocompatibility, degradability, and natural bioactivity and are widely used in the development of bio-based materials. We provide a high-quality development service for disaccharide-based biodegradable materials based on the principle of non-toxicity to humans and the environment during use and disposal.
We develop biodegradable materials ranging from polyurethane foams for industrial applications to hydrogels for biomedical applications. There are two main strategies for our development. One is the direct polymerization of disaccharides as raw materials. The other is to incorporate disaccharides into synthetic polymers. We are proficient in technologies related to the development of disaccharide-based biodegradable materials, such as injection, direct blending, extrusion, foaming, and solvent casting. The process of developing disaccharide-based biodegradable materials is as follows:
Fig.1 Flowchart of disaccharide-based biodegradable material development. (CD BioGlyco)
We have further subdivided this service into two parts to better support and serve our clients in the development of biodegradable materials.
Sucrose is an attractive raw material due to its hydrophilic nature and large number of hydroxyl functional groups. CD BioGlyco is skilled in technologies related to biodegradable materials based on sucrose, including compression molding, reaction extrusion, etc.
Lactose is rich in hydroxyl functional groups and is easily functionalized, making it attractive as a raw material for the preparation of hydrophilic materials. CD BioGlyco develops biodegradable materials such as lactose-based films and hydrogels for food packaging and drug delivery.
Technology: Direct blending
Journal: Journal of Applied Polymer Science
IF: 1.866
Published: 2015
Results: In this study, new functional elastic polyurethane foams (PUF) were synthesized from isocyanate precursors based on disaccharides (sucrose, lactose, maltose). The material retains the inherent properties of conventional foams and is degradable under both biotic and abiotic environmental factors. This study provides an effective strategy for the development of disaccharide-based biodegradable materials.
Fig.2 FTIR-spectra of synthesized PUF: (1) PUF-M, (2) Lactose, (3) PUF-4. (Savelyev, et al., 2015)
Compared to other synthetic polymers, carbohydrate-based biomaterials are biocompatible, biodegradable, and non-immunogenic, making them particularly suitable for in vivo therapeutic research, food packaging, wastewater treatment, and other applications.
Biomedical degradable materials generally refer broadly to all materials that are degradable and absorbable in living organisms, i.e., materials that can be progressively broken down or destroyed when implanted in the body and over some time. The material will break down or degrade into non-toxic small molecules and be eliminated from the body without the need for a second surgery after its mission is accomplished. The constituent units or degradation products of most biomedical degradable materials are small molecules that exist in the organism itself, which have better biocompatibility and biosafety than non-degradable materials. The basic requirements are good biocompatibility, non-toxicity of the polymer itself and the degradation products; the required degradation rate, appropriate physical and mechanical properties, and moldability.
CD BioGlyco has made good progress in the development of biodegradable materials based on carbohydrates. We focus on where our clients need us and give good solutions. Please feel free to contact us for more details about disaccharide-based biodegradable material development.
References