Inherited genomic instability is the basis of tumorigenesis and the driving force behind the continuous growth of tumors. Genomic instability can be defined as an increase in the frequency of genomic mutations that can initiate oncogene activation and tumor suppressor gene inactivation, perturb apoptosis, proliferation, cell cycle, etc. Both genomic instability and reprogramming of glucose metabolism are key hallmarks of tumors. Glucose metabolism reprogramming affects DNA damage and DNA damage response by modulating the metabolite pool, resulting in an increase in the frequency of genome mutations. In turn, the DNA damage response affects metabolic pathways. Response to Glucose Metabolism Regulators. Therefore, investigating the relationship between glucose metabolism reprogramming and genomic uncertainty is of great significance for the development of combination therapeutic strategies. CD BioGlyco can provide analytical services for the relationship between glucose metabolism reprogramming and genome stability.
Fig. 1 The relationship between glucose metabolism reprogramming and genomic instability
Repairing DNA damage to maintain genome integrity is a key biological process for tumor resistance to chemotherapy. The study shows that changes in glucose metabolism are closely related to the DNA damage response. Through the MOPCGM platform, we use multi-omics technology to integrate glucose metabolomic information with genomics information to analyze the interplay between glucose metabolic reprogramming and DNA damage response.
We can provide the following specific services, including but not limited to:
Analysis of the role of glucose metabolism-related proteins on DNA damage repair
Screening of glucose metabolism-related genes involved in DNA repair
Searching for new components of DNA damage response involving sugar metabolism
Based on the MOPCGM platform, we provide analysis services for the interaction between glucose metabolism and DNA damage response. Identifying interactors of DNA repair proteins by proteomics and identifying glucose metabolites that regulate DNA repair by metabolomics. Identification of novel genes involved in DNA repair pathways and sugar metabolism processes through chemical and genetic screening.
CD BioGlyco can analyze the relationship between glucose metabolism and DNA response pathways, understand the relationship between glucose metabolism reprogramming and genome stability, and explore combined therapeutic strategies targeting glucose metabolism and DNA damage. Our experienced teams of scientists, researchers, and technicians provide a fast turnaround, and high-quality services at competitive prices for worldwide customers. Our customers have direct access to our staff and prompt feedback on their inquiries. If you are interested in our services, please contact us for more details.
