Professional Poliomyelitis Vaccine in Dragee Candy Evaluation That Exceeding Your Expectations

CD BioGlyco has accumulated many years of experience in Pharmaceutical and Biological Analysis. Our professional analytical team provides high-quality Biological Evaluation services including Typhoid Vaccine Evaluation, Group A Meningococcal Polysaccharide Vaccine Evaluation, 23-Valent Pneumococcal Polysaccharide Vaccine Evaluation, Haemophilus influenzae Type b Conjugate Vaccine Evaluation and poliomyelitis vaccine in dragee candy evaluation services. Poliomyelitis vaccine in dragee candy is made by inoculating human diploid cells or primary monkey kidney cells with attenuated strains of poliovirus types I, II, and III, respectively, and then making sugar pills after culturing and harvesting the viral fluids to prevent poliomyelitis. Moreover, our lab provides reliable Pharmaceutical Analysis and Pharmaceutical Excipient Analysis.

• Single virus harvest analysis
  • Titration of virus: CD BioGlyco uses microcytopathic assay to test viral titers. The virus is diluted and inoculated with Hep-2 cells or other sensitive cells, culture, and the results are recorded.
  • Sterility test and mycoplasma test: CD BioGlyco provides professional sterility test and mycoplasma test services to clients. Our researchers examine mycoplasma by both culture methods and indicated cell culture (DNA staining) to ensure accurate data for our clients.
• Monovalent bulk analysis
  • Identification: Monovalent poliovirus-specific immune serum of type I, II, or III is mixed with the appropriate amount of viral test material and inoculated into Hep-2 cells or other sensitive cells after a water bath. The cells are incubated for 7 days at 35~36°C and the viral type is determined. Notably, our researchers set up the serum and cell controls. Serum and cell controls are negative and viral controls are positive.
  • Test: CD BioGlyco provides satisfactory virus titration, monkey neurovirulence testing (NVT), sterility testing, and mycoplasma testing services. For NVT, we select healthy rhesus macaque of appropriate body weight and check serum for the absence of neutralizing antibodies to the same type of virus. Then, we observe the status of the rhesus monkeys by either the spinal injection method or the intracerebral injection method. We take central nervous system sections for histologic examination to observe lesions in animals that die midway and are due for execution.
• Final bulk analysis
  • For final bulk, we mainly provide virus titration and sterility testing services.
• Final product analysis
  • Basic test: We provide various basic tests including vaccine identification, weight difference, virus titration, heat stability test, microbiological examination, and uniformity of the virus distribution.
  • Pathogenic bacteria test: We mainly provide the following three pathogenic bacteria testing services including Srpococcus hemolyticus, enteric pathogens, and Escherichia coli. For S. hemolyticus and enteric pathogens, diluted test material is inoculated with GN or broth medium and then transferred to a plate of identification medium with the aid of scribing to see if there is any growth of pathogenic bacteria. For E. coli, take the diluted product to be tested and inoculate it with inoculated ordinary Kessler's medium or McConkey's broth medium and observe the gas and acid production phenomena.

Publication Data

Applications of Poliomyelitis Vaccine in Dragee Candy Evaluation

• Poliomyelitis vaccine in dragee candy evaluation facilitates the development and formulation optimization of polio vaccines.
• Poliomyelitis vaccine in dragee candy evaluation lays the groundwork for the evaluation of other sugar pill vaccines.
• Poliomyelitis vaccine in dragee candy evaluation plays an important role in the control and elimination of polio.

Advantages of Us

• Based on our high standards and strict requirements, we are committed to providing the most perfect analytical solution for each client.
• Our operational team has strong background knowledge and extensive operational experience in poliomyelitis vaccine in dragee candy evaluation.
• Our researchers provide reliable cellular and animal related services with years of industry experience.
• In monovalent bulk analysis, our researchers construct control groups and parallel experiments to ensure optimal data delivery.

CD BioGlyco is committed to providing our clients with the most assured and reliable analytical services. We want to be your dedicated partner in pharmaceutical and biological analysis. We encourage you to contact us if you have any concerns.