Hot Glycans
CD BioGlyco provides a comprehensive range of high-quality carbohydrate products to meet a variety of research and industrial needs. From N/O-glycans for vaccine and drug development to human milk oligosaccharides (HMOs) supporting microbiome research and infant nutrition research, and blood group and Lewis antigens for immunology research. Our products also include glycoconjugates to support advanced biochemical analysis, glycosaminoglycans (GAGs) for structural biology and cell signaling research, cyclodextrins to improve solubility and stability of drug formulations, and glycolipids that play an important role in membrane biology research. Our products range in quantity from milligrams for precise research applications to kilograms for large-scale industrial processes and are rigorously tested to ensure the highest purity and consistency. We also provide custom synthesis services to develop customized carbohydrate solutions based on our clients' unique needs.
Our carefully crafted, high-quality N-glycan products meet the diverse needs of researchers and scientists exploring the complex world of glycobiology. These products are characterized by high purity and diverse structures and are used in fields such as oncology, immunology, and biopharmaceutical development, providing reliable and consistent results for your experiments. Trust our high-quality products to push your research to new heights, promoting innovation and discovery in the evolving field of scientific exploration. In addition, we also provide excellent custom synthesis services for N-glycan products. Whether you need a complex N-glycan structure or a unique modification, our experienced team of experts uses advanced technologies and methods to provide unparalleled results.
Fig.1 Types of N-glycans. (CD BioGlyco)
We offer an exceptional range of high-quality O-glycan products that are carefully designed to help you unlock the potential of scientific research. Our O-glycans are precisely synthesized and are always committed to quality assurance, ensuring that our clients receive the highest quality research materials. Whether your focus is glycoprotein research, disease biomarker discovery, or therapeutic development, our wide range of O-glycan products are an indispensable resource in your exploration toolkit, such as T antigen, Tn antigen, sialyl T antigen, core 2, core 3, core 4, core 5, core 6, core 7, core 8. We are committed to advancing scientific research by providing customized synthesis solutions to meet a variety of needs from milligrams to kilograms.
Fig.2 O-Glycan structures. (CD BioGlyco)
HMO is the third most abundant component in breast milk. Currently, more than 200 HMOs have been identified, including neutral oligosaccharides and acidic oligosaccharides. Neutral oligosaccharides are divided into non-fucosyl and fucosyl oligosaccharides, accounting for about 75% to 85% of HMOs. Acidic oligosaccharides are oligosaccharides containing sialic acid and sulfate structures, accounting for about 10% to 15% of HMOs. HMOs promote healthy intestinal flora, enhance immune function and resist pathogens, and play a key role in infant nutrition. We have launched a series of high-quality HMO products designed for scientific research and innovation, such as 2'-fucosyllactose (2'FL), lacto-N-neotetraose (LNnT), difucosyllactose (DFL), lacto-N-tetraose (LNT), 3-sialyllactose (3'SL), 6'-sialyllactose (6'SL). These products are synthesized with the highest purity and consistency standards to ensure reliable results for your pioneering research. Whether you are exploring the health benefits, biological functions, or potential therapeutic applications of HMOs, our products provide a solid foundation for your research.
Fig.3 HMO structures. (Masi & Stewart, 2022)
Many oligosaccharides linked to proteins and lipids in cells are involved in many different biological processes. Various complex sugar chains with terminal Lewis epitopes are covalently linked to proteins and lipids to form glycoconjugates or exist alone as free glycans. These free glycans and glycoconjugates mediate the interaction between cells and the extracellular environment and play a vital role in many physiological and pathological processes. Our high-quality blood group and Lewis antigen series are designed to meet scientific research needs, such as Lewis A, Lewis B, Lewis X, Lewis Y, blood group A, blood group B, and blood group H. Each antigen product in our series has been carefully developed and thoroughly tested to provide high specificity and consistency to meet the needs of various hematology and immunology research.
Fig.4 Biosynthesis pathway of histo-blood group antigens (HBGAs). (Barbé, et al., 2018)
We conjugate sugars with other biomolecules such as polyacrylamide (PAA), biotin, PAA-biotin, and PAA-fluorescein (FITC) to generate unparalleled specific glycoconjugates, which have a wide range of applications in anti-cancer drug development, vaccine research, etc. Sugar molecules conjugated with PAA, biotin, PAA-biotin, and PAA-FITC include but are not limited to:
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Our excellent GAG product line includes heparin, heparin sulfate (HS), hyaluronic acid (HA), chondroitin sulfate (CS), dermatan sulfate (DS), and keratan sulfate (KS). Each is carefully quality-controlled to ensure maximum efficacy and reliability in your research applications. We also provide labeled GAG products that provide enhanced functionality for a variety of experimental requirements, such as biotinylated CS, FITC-CS, AMCA-HA, etc. These products are essential tools for researchers to deeply study complex biological processes, enabling precise studies of cell signaling, molecular interactions, and therapeutic development.
We carefully develop a comprehensive range of cyclodextrin products, from α-cyclodextrin, β-cyclodextrin, and γ-cyclodextrin, to complex anionic cyclodextrins, cationic cyclodextrins, cyclodextrin polymers, nonionic cyclodextrins, fluorescently labeled cyclodextrins, etc. These cyclodextrin products are known for their unique inclusion complex capabilities, enhancing the solubility and stability of different compounds in the pharmaceutical and chemical industries. We provide products ranging from gram-level products for research purposes to kilogram-level products for the special needs of the pharmaceutical and specialty fine chemicals industries. Our commitment to quality and excellence makes us your trusted partner to help you advance scientific research and achieve breakthrough results.
Fig.5 Schematic structure of native α, β, and γ-cyclodextrins. (Napiórkowska & Szeleszczuk, 2024)
Glycolipids are an elegant bridge between lipid and carbohydrate functions, playing a vital role in energy balance, cell recognition, and signal transduction. We provide clients with a wide range of glycolipids, including lacto-series glycolipids, globo-series glycolipids, and ganglio-series glycolipids, to advance the complex study of cell communication and unravel the mystery of the lipid bilayer coding.
Fig. 6 Simplified scheme of glycosphingolipid (GSL) biosynthesis. (Wallom, et al., 2022)
As a leader in the field of glycobiology, we are proud to offer a wide range of high-quality dextran products to meet the needs of researchers and industry professionals worldwide. Our products include carefully crafted dextran amine, lysine-dextran, phenyl-dextran, FITC-Q-dextran, TRITC-dextran, DEAE-dextran, lysine-dextran, FITC-lysine-dextran, TRITC-lysine-dextran, FITC-dextran sulfate, biotin-dextran-FITC, FITC-DEAE-dextran and many more. These versatile products are important tools for biochemical research, cell imaging, and drug delivery systems, providing reliable results and greater efficiency. Whether you are conducting cutting-edge research in molecular biology or developing groundbreaking pharmaceutical solutions, our dextran products provide you with the consistency and precision you need to achieve breakthrough discoveries.
DOI: 10.1136/gutjnl-2023-330301
Journal: Gut
IF: 23.1
Published: 2024
Results: The study found that 2'FL reduced body weight and fat mass gain in mice fed a high-fat diet (HFD). To explore the mechanism of action of 2'FL, the authors designed a series of experiments to elucidate whether the metabolic effects of 2'FL are associated with changes in intestinal mucus production, glycosylation, secretion, and degradation. The results showed that 2'FL counteracted diet-induced obesity and metabolic alterations, while affecting mucus production, secretion, and glycosylation, as well as gut microbiota composition, bacterial glycosyl hydrolases, fecal proteome, and endocannabinoid (eCB) system. Together, these data pave the way for further investigation of new strategies and targets for the prevention and treatment of obesity and related diseases.
Fig.7 The expression analysis of genes in the jejunum, ileum, caecum and colon. (Paone, et al., 2024)
CD BioGlyco aims to provide excellent products and services that meet the highest standards of quality and innovation. We are committed to advancing your research and meeting your unique needs, providing tailor-made solutions and expert guidance. Welcome you to feel free to contact us with any questions, we are eager to help and cooperate with you to achieve your research and industrial goals.
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