The Biological Significance of Mannose

Mannose is a monosaccharide with the chemical formula C₆H₁₂O₆, which is a tautomer of glucose. They have the same chemical formula but different molecular structures. There are many types of mannoses, and a mannose includes at least 30 different isomers. The most common of them are α-D-mannose, β-D-mannose, α-L-mannose, β-L-mannose, etc. Mannose is involved in carbohydrate metabolism processes in living organisms and it is also involved in intercellular interactions. For example, in the interaction between glycoproteins of cell membranes and the extracellular matrix, mannose groups on glycoproteins can interact with a variety of proteins, thereby regulating the viscosity of the extracellular matrix, protein distribution, and function. In addition, mannose is thought to modulate the immune system and enhance resistance to disease in the body. In addition, mannose is thought to regulate the body's immune system and enhance disease resistance.

Fig.1 Structure of mannose. (Wikipedia)

High-Throughput Screening (HTS) of Mannose at CD BioGlyco

Mannose is a monosaccharide that is one of the most essential sources of energy in living organisms. As a provider of HTS service, CD BioGlyco utilizes specialized knowledge and experience to provide clients with mannose HTS services based on multiple technologies. Our services encompass a wide range of offerings, including but not restricted to:

• HTS of mannose by Microchip-Based Assay
  This technology uses microchips as the analytical matrix, allowing for high sample density analysis and massively parallel analysis, and requires very small sample volumes, typically only a few microliters for analysis.
• HTS of mannose by Automated Liquid Chromatography-Mass Spectrometry (Automated LC-MS)
  We combine HPLC and mass spectrometry to isolate and identify specific metabolites, such as mannose, by large-scale sample analysis.
• HTS of mannose by Ultra-High Performance Liquid Chromatography (UHPLC)
  This technology is of higher resolution compared to traditional HPLC techniques, allowing for the separation of more compounds and metabolites, and improving the accuracy of the assay. It uses less sampling volume, so more samples can be analyzed faster.

Fig.2 Strategies for high-throughput mannose screening. (CD BioGlyco)

Applications

• Vaccine development
• Research on glycosylated drugs
• Studies on the interaction of glycans with biomolecules

Advantages of Us

• The small number of samples required
• Higher resolution and improved detection accuracy
• 24/7 availability

CD BioGlyco has extensive experience in the HTS of glycans. We have been working on research on the metabolism of glycoconjugates for many years and provide efficient, cost-effective, and hassle-free mannose HTS services for our clients. If you are interested in our services or have any questions about our products, please feel free to contact us.