Overview

Glyconanoparticle offers several advantages in delivering drugs, including good biocompatibility, biodegradability, stability, targeted accumulation, increased penetration through the blood-brain barrier, and reduced side effects. It aids drug absorption by targeting specific sites in brain cells. CD BioGlyco focuses on the pharmaceutical sector and provides a one-stop neurological drug-loaded glyconanoparticle formulation service for Alzheimer's disease and Parkinson's disease (PD) based on our GlycoNano™ Platform. We have extensive hands-on experience and the ability to customize glyconanoparticles by developing high-quality nano-delivery systems to facilitate improved drug delivery efficiency, bioavailability, and therapeutic efficacy in preclinical models.

Integrated and Innovative Neurological Drug-loaded Glyconanoparticle Formulation Service

With expertise and experience in glyconanoparticle development, our laboratory staff provides solutions for everything from glyconanoparticle development to final drug release studies. Specific services include the following:

Alzheimer's Disease

Alzheimer's disease is a neurological disorder that causes behavioral and cognitive impairments. Traditional therapeutic drugs are limited by their poor solubility and low bioavailability. We design, produce, and characterize glyconanoparticles and analyze their potential to deliver relevant drugs to the brain.

PD

Current PD therapies mainly target dopamine or its precursor (levodopa). These therapies are hampered by their blood-brain barrier and poor bioavailability. For this reason, we develop multiple glyconanoparticles for targeted delivery of multiple drugs.

Below is the general flow of our services:

Glyconanoparticle design

We develop glyconanoparticles for many types of neurological drugs. The design of the nanoparticles involves controlling the particle size, surface area, and surface properties to carry the necessary amount of drug. Ultimately the glyconanoparticle exerts the desired pharmacological activity by releasing the drug to achieve site-specific therapeutic effects.

Development of Glyconanoparticles

We are skilled in various methods of preparing glyconanoparticles. After understanding the specific glyconanoparticle requirements, we select appropriate methods to develop glyconanoparticles including hydrophobic effects, click chemistry, nucleophilic substitution, coulombic interactions, etc. The glyconanoparticles are modified to improve their stability. The final prepared glyconanoparticles are stable, biodegradable, and provide a sustainable drug release profile. In addition to this, Glycol Nanohydrogel is also developed by us for targeted drug delivery.

Characterization and Preclinical Studies of Glyconanoparticles

We combine various experimental methods to analyze the physical and chemical properties of glyconanoparticles, including particle size, surface charge, chemical composition and morphology, and interactions. In addition, we also analyze the effect of pH, drug concentration, etc., on the embedding efficiency, and combine adsorption tests and drug release tests to analyze the safety and efficacy of glyconanoparticles for drug delivery.

Our services include but are not limited to the following drugs:

Workflow

We have a team of professionals with rich experience in Glyconanoparticle Formulation to provide a neurological drug-loaded glyconanoparticle formulation service to our clients. Our researchers use core technologies to develop high-quality glyconanoparticles for optimal drug loading without compromising drug stability, ensuring targeted delivery and minimizing off-target effects.

Applications

• The glyconanoparticle is loaded with neurological drugs to enable drug targeting and to improve therapeutic efficacy in the treatment of neurological diseases such as PD and Alzheimer's disease.
• The glyconanoparticle is used to deliver neurological drugs and has an important role in the development of co-administration strategies.
• Neurological drug-loaded glyconanoparticle formulation plays an important role in the development of personalized therapeutic strategies for neurological diseases.

Advantages

• We have extensive expertise in nanotechnology and pharmaceutical formulation and specialize in developing tailored experimental protocols for each specific research goal.
• We conduct detailed characterization and comprehensive preclinical studies of glyconanoparticles to meet specific drug delivery requirements.
• Rigorous testing and evaluation ensure the safety and efficacy of glyconanoparticles in drug delivery applications.

Publication Data

Frequently Asked Questions

• What types of drugs are glyconanoparticles used to load?
  Glyconanoparticles are used to load a wide variety of drugs, including small molecules, peptides, nucleic acids, proteins, etc., in neurological disorders such as Alzheimer's disease and PD. Without compromising drug stability, glyconanoparticles are used for targeted delivery of drugs to specific targets to enhance biocompatibility and improve therapeutic efficacy.
• How to get started with neurological drug-loaded glyconanoparticle formulation services?
  You can contact our service team through our website or directly by email. We are the first to work with you to discuss specific project requirements, timelines, and any other details needed to initiate experiments.

CD BioGlyco draws on its extensive experience in glyconanoparticle development to provide an integrated and innovative neurological drug-loaded glyconanoparticle formulation service from design and preparation to final preclinical studies. We are committed to innovation and provide extensive support for research into neurological disease therapies. Welcome to contact us if you are interested in this service or have a request.