CD BioGlyco is committed to technological innovation and research and development, keeping a real-time eye on glycol nanohydrogel developments and providing our clients with continuous technical support and innovative power. To this end, we launch a glycol nanohydrogel development service and provide cutting-edge solutions.
Get a Quote NowThe unique properties and nanoscale size of glycol nanohydrogel enable it to be taken up by cells through endocytosis and then release its contents into the cytoplasm through different stimuli. As a result, glycol nanohydrogel offers additional advantages over conventional nanocarriers, such as good targeting, superior encapsulation efficiency, enhanced permeability, and lower cytotoxicity. CD BioGlyco provides a one-stop glycol nanohydrogel development service, including design, preparation, formulation optimization, characterization, preclinical studies, and application evaluation. Our proprietary glycol nanohydrogel synthesis technology ensures high encapsulation rates and uniform particle size distributions and provides extensive support for advancing their applications.
Fig.1 Sources and advantages of nanohydrogels. (Quazi & Park, 2022)
Based on the advanced GlycoNano™ Platform and the ability to precisely control uniform particle size, we offer integrated development services and prepare glycol nanohydrogel with high encapsulation efficiency. Regardless of the type of customized glycol nanohydrogel you need, we offer a specific solution for your specific research needs and ensure high precision and quality every step of the way.
Adjusting the proportions of various components, synthesis temperature, time, etc., has an impact on the properties, structure, and functionalization of glycol nanohydrogel. Based on our extensive practical experience, we select appropriate methods to customize glycol nanohydrogel formulations that precisely deliver the active substance to suit the specific drug, application, and delivery method.
We select suitable polymeric materials based on the target application and develop various glycol nanohydrogels using various polymers. Commonly used polymers include natural polymers such as chitosan, and gelatin, and synthetic polymers such as polylactic acid (PLA). These compounds functionalize and tailor the hydrogel surface to enhance its interaction with the biological environment or attach specific ligands for targeting purposes. In this process, we consider biocompatibility, hydrogel size, and detailed applications and synthesize glycol nanohydrogel using various methods such as precipitation polymerization, and inverse emulsion polymerization.
Natural polymers come from a wide variety of sources and offer various advantages. Glycol nanohydrogel engineered from natural sources has attracted a lot of attention due to its wide range of applications in agriculture, tissue engineering, cancer therapy, and drug delivery. Isolated polymers of natural origin such as gelatin, chondroitin, alginate, branched chain starch, etc., are known as natural polymers. We use several different strategies to develop glycol nanohydrogel based on various natural polymers, including the following:
Synthetic polymers are a class of polymers that includes materials consisting of long molecular chains connected by organic linkages. They have a controlled structure, desired mechanical properties, and tunable biodegradability, and are used to prepare glycol nanohydrogel by cross-linking, etc. Commonly used synthetic polymers include PLA, polyvinyl alcohol (PVA), polylactic-co-glycolic acid (PLGA), poly(l-lactic acid) (PLLA), and polydioxanone (PDO), and are suitable for applications such as biomedical applications. Based on our extensive experience in glycol nanohydrogel development, we offer the following glycol nanohydrogel manufacturing services:
The size and distribution of glycol nanohydrogel will affect its embedding characteristics, stability, release behavior, pharmacokinetics, and other properties. We characterize the Physicochemical Properties and Interactions of glycol nanohydrogel to ensure that its structure and properties are as expected. These are typically characterized by dynamic light scattering (DLS), atomic force microscopy (AFM), transmission electron microscopy (TEM), and others.
We conduct detailed in vitro and in vivo studies using abundant In Vivo and In Vitro Models to analyze the properties, biodistribution, and efficacy of glycol nanohydrogel, such as biocompatibility, cytotoxicity, drug release kinetics, and safety. Depending on the specific application and desired properties of glycol nanohydrogel, the methods and considerations required for the assay vary widely. Preclinical study protocols for different glycol nanohydrogel are customized to meet the specific needs of the intended use.
The loading and loading rate of glycol nanohydrogel encapsulated actives are examined and further analyzed for their effect on the stability of the actives.
Due to long-term storage, the conformation of glycol nanohydrogel may change, resulting in delivery efficiency. It is necessary to determine the Physical, Chemical, and Storage Stability of glycol nanohydrogel. We simulate various environments and determine the stability of glycol nanohydrogel under different conditions.
Cytotoxicity, Uptake and Trafficking, and Immune Responses to glycol nanohydrogel are evaluated by assaying cell proliferation, apoptosis, activity, and cytokines using various cellular and animal models.
The assessment of the pharmacodynamics of glycol nanohydrogel included a Dose-Response Study, Mechanism of Action Study, Tumor Xenograft Study, and Wound Healing Study.
We study the Absorption, Biodistribution, Metabolism, and Excretion of glycol nanohydrogel through in vivo and in vitro experiments, and calculate the half-life of glycol nanohydrogel.
We evaluate the safety pharmacology of glycol nanohydrogel to ensure that it is suitable for specific applications such as drug delivery and skin repair.
We conduct detailed tests on the release efficiency and encapsulation efficiency of glycol nanohydrogel and evaluate their potential applications in pharmaceuticals, cosmetics, and agriculture.
Technology: Nanoprecipitation self-assembly
Journal: Nanomaterials
IF: 5.719
Published: 2021
Results: In this study, a new glyconanoparticle was constructed by nanoprecipitation self-assembly, consisting of polystyrene-block-maltoheptaose and polystyrene-block-β-cyclodextrin. The structure, morphology, and size of the glyconanoparticle were characterized by DLS and SEM. The glyconanoparticle may have good applications in biotechnology, cosmetics, and biomedicine through modification. It may also be developed for enzyme biofuel cells, for example, to convert chemical energy into electrical energy.
Fig.2 Complete development process of glyconanoparticles. (Carrière, et al., 2021)
CD BioGlyco has many years of expertise in the field of glycol nanohydrogel and continues to provide our collaborators with tailored solutions for glycol nanohydrogel development. If you are looking for the right glycol nanohydrogel for your specific project, we are ready to help you. Please feel free to contact us and discuss your project together.
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