Glycol nanohydrogel is an adaptable and versatile biomaterial with nanoscale dimensions, comprising natural and synthetic polymers or their blends. Its smaller size and superior performance, compared to larger hydrogels and other types, render it ideal for stimuli-responsive drug delivery and various other applications. CD BioGlyco has established the robust GlycoNano™ Platform, providing a comprehensive glycol nanohydrogel development service that encompasses synthesis, purification, and characterization. This service is grounded in a broad spectrum of methodologies tailored to meet clients' research needs.
Drawing from our extensive experience in Developing Glycol Nanohydrogel, we employ diverse techniques to synthesize a range of glycol nanohydrogels tailored for specific attributes such as stability and responsiveness. We meticulously consider factors including surface properties, application scope, functional groups, and degradability, ensuring optimal process refinement. Here's an overview of our service:
We dissolve the monomer and crosslinker in the reaction medium water. In the presence of an initiator, the polymer chains generated during the polymerization process grow to a certain length and then phase separation occurs to form polymer colloidal particles and further cross-linking structures, resulting in nanohydrogels.
In this method, monomers and crosslinkers are dispersed in the organic solvent in the presence of the oil-soluble emulsifier to make an inverse emulsion using an appropriate emulsification method (e.g., mechanical stirring emulsification, homogeneous emulsification, membrane emulsification, or microfluidic emulsification, etc.). The polymerization of the monomer and crosslinker is then initiated, and the nanohydrogels are finally obtained by removing the organic solvent and emulsifier. We have optimized the entire synthesis process to ensure that glycol nanohydrogel is of high quality and suitable for specific research purposes.
We first add the aqueous solution of monomer and crosslinker to the microtemplate, and then the monomer and crosslinker in the microtemplate undergo the free radical polymerization reaction by chemical initiation or photoinitiation. The formed glycol nanohydrogel is separated from the micro template. This method has more advantages, including the ability to prepare nanohydrogels with different shapes, and relatively easy encapsulation of cells or other bioactive components.
We precipitate certain water-soluble polymers from the homogeneous aqueous solution to form nanoparticles by heating, pH adjustment, or ionic strength. Then, the cross-linking reaction such as chemical cross-linking or photocross-linking is used to produce a cross-linking structure of the polymers within the particles to produce glycol nanohydrogel.
In this method, the polymer used to synthesize glycol nanohydrogel is first dispersed in the organic solution using the oil-soluble surfactant to make the W/O inverse emulsion. Then the water-soluble crosslinking is added to make a cross-linking reaction between the polymers. After removing the organic solvent and surfactant, the glycol nanohydrogel stably dispersed in water is finally obtained. This method is also suitable for the synthesis of nanohydrogel with small particle sizes.
Molecular self-assembly is the process by which molecules spontaneously form thermodynamically stable aggregates with a well-defined ordered structure through non-covalent bonding interactions (hydrogen bonding interactions, electrostatic interactions, hydrophobic interactions, van der Waals forces, etc.). Water-soluble polymers with a specific structure form well-stabilized glycol nanohydrogels driven by these weak interactions and combined with methods such as chemical crosslinking or photocrosslinking, etc. This method is suitable for the preparation of natural polymer-based and graft-modified glycol nanohydrogels under mild conditions.
We add the polymer precursors for the formation of nanohydrogels into the micro templates, and then the glycol nanohydrogel is finally produced by chemical cross-linking, photo-cross-linking, etc. The synthesis parameters of the whole process are optimized to ensure.
We customize glycol nanohydrogel based on composition/structure, synthetic method, stimulation reactivity, application, etc. The development process of glycol nanohydrogel includes the following and the synthesis, purification, and freeze-drying parameters are optimized.
A wide variety of monomers are available, including natural products and synthetic polymers. We choose the appropriate method for the preparation.
We synthesize glycol nanohydrogel by utilizing abundant natural polymers, including glycoproteins (collagen, gelatin), Carbohydrates (agarose, starch, etc.), glycosaminoglycans (hyaluronic acid, chondroitin sulfate), and so on.
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A wide variety of synthetic polymers including Polylactic Acid (PLA), Polyvinyl Alcohol (PVA), etc., are used to synthesize glycol nanohydrogel. We provide a one-stop glycol nanohydrogel production service.
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This process involves the purification of glycol nanohydrogel by centrifugation or dialysis to remove unreacted material and other impurities. The entire purification process has been optimized to ensure the quality of the glycol nanohydrogel.
We use dynamic light scattering, scanning electron microscopy (SEM), transmission electron microscopy (TEM), and other technologies to analyze the shape, size, mechanical properties, swelling rate, biocompatibility, electrochemical behavior, etc., of the glycol nanohydrogel.
Technologies: Self-assembly/crosslinking, SEM, TEM
Journal: Pharmaceutics
IF: 4.421
Published: 2019
Results: In this study, a polysaccharide-based nanohydrogel was constructed by a self-assembly/crosslinking method. The researchers obtained a cationic derivative of pullulan polysaccharide through a grafting reaction and formed a crosslinked nanohydrogel together with dextran sulfate. The nanohydrogel is colloidally stabilized and the size and surface charge can be controlled by the polycation/polyanion ratio. Observation of the morphology of the nanohydrogel by SEM and TEM revealed that the resulting structure was spherical with a hydrodynamic diameter in the range of 100-150 nm. Upon binding with cationic branched starch, the nanohydrogel could effectively encapsulate the drug and release it in a controlled manner.
Fig.1 Preparation flow of polysaccharide-based nanohydrogel. (Lachowicz, et al., 2019)
At CD BioGlyco, our customized glycol nanohydrogel development service provides strong support for accelerated research in the areas of targeted drug delivery, biosensors, and medical diagnostics for our clients. Please feel free to contact us if you are interested in our glycol nanohydrogel development services. We are looking forward to cooperating with you to promote the development of nanohydrogel.
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