The polysaccharide conjugation reaction based on physical cross-linking is a method that uses the polymeric self-assembly properties of polysaccharides for linkage. This method achieves the attachment of the polysaccharide to the target substance by controlling the physical conditions of the polysaccharide solution. A commonly used method in polysaccharide conjugation reactions for physical crosslinking is to exploit the gelation properties of polysaccharides. Polysaccharides form a gel network structure under appropriate conditions to interconnect polysaccharide molecules by physical crosslinking. Meanwhile, the target substances enter the polysaccharide gel by adsorption and diffusion and interact with the polysaccharide molecules. In addition, physical crosslinking of polysaccharide conjugation also utilizes temperature-sensitive polysaccharides. They have the property of swelling and gelation in a specific temperature range. By controlling the temperature, a reversible shift of polysaccharide swelling and gelation can be achieved, thus regulating the attachment and release of polysaccharides to the target substance.
Physical cross-linking-based polysaccharide conjugation reaction is an effective method to achieve linkage and functional enhancement of polysaccharides with other substances, which has a wide application potential. CD BioGlyco has developed a comprehensive Glyco™ Vaccine Development Platform to provide Polysaccharide Conjugation Services based on various Technologies.
CD BioGlyco provides our clients with physical crosslinking-based polysaccharide conjugation services using advanced technology. Our dedicated team provides customized solutions and expert advice for our clients to help them accelerate their R&D process. If you are interested in our services, please contact us for more detailed information.
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