Cell Surface Glycoengineering Service

Importance of Cell Surface Glycoengineering

Fig.1 Cell surface display of defined glycans.
(Nischan & Kohler, 2016)

Cell surface glycoengineering is an emerging technology that regulates the biological behavior and function of cells by manipulating the synthesis and modification process of cell surface glycoproteins and glycolipids, and changing the structure and composition of cell surface sugar chains. The glycans displayed on the cell surface determine how the cell interacts with other cells and molecules in the environment. Therefore, methods to control glycan expression are valuable tools for understanding and modulating the biological functions of cell surface glycoconjugates. Cell surface glycoengineering services can provide an in-depth understanding of their biological functions and provide new targets for disease diagnosis and treatment.

Cell Surface Glycoengineering Service at CD BioGlyco

Cell surface glycans play critical roles in a wide range of cellular functions, including adhesion, signaling, and immune responses. By engineering these surface glycans, scientists tailor the behavior of cells for a variety of applications. CD BioGlyco provides the most efficient and up-to-date strategies for cell surface glycoengineering, including but not limited to what is shown in Fig.2.

Fig.2 Strategies for cell surface glycoengineering. (CD BioGlyco)

CD BioGlyco brings cutting-edge biotechnology to cell surface glycoengineering. Our cell surface glycoengineering services include these 8 types: N-glycan glycoengineering, O-glycan glycoengineering, glycosylphosphatidylinositol (GPI) anchor glycoengineering, glycosaminoglycans (GAG) glycoengineering, glycolipid glycoengineering, glycoprotein glycoengineering, blood group antigens glycoengineering, and sialic acid glycoengineering. We believe our suite of services meets clients' research and biotech needs.

Cell Surface N-glycan Glycoengineering Service

CD BioGlyco offers a cell surface N-glycan glycoengineering service, which involves manipulating glycosyltransferase to modify the structure and composition of cell surface N-glycans.

Cell Surface O-glycan Glycoengineering Service

At CD BioGlyco, cell surface O-glycan glycoengineering service will help clients modify the structure and composition of cell surface O-glycans, thereby regulating cellular functions such as immune response.

Cell Surface Glycosylphosphatidylinositol (GPI) Anchor Glycoengineering Service

At CD BioGlyco, GPI anchor glycoengineering service helps clients investigate physiological processes such as cell growth and immune response, as well as pathological processes such as tumor metastasis and infection.

Cell Surface Glycosaminoglycans (GAG) Glycoengineering Service

At CD BioGlyco, cell surface GAG glycoengineering service modifies the structure and composition of GAGs to regulate cell signaling and cell-cell interactions, providing new drug development insights.

Cell Surface Glycolipid Glycoengineering Service

At CD BioGlyco, cell surface glycolipid glycoengineering service provides customized glycolipid structures to regulate cell growth, differentiation, and other functions, offering strong support for drug development and biomedical research.

Cell Surface Glycoprotein Glycoengineering Service

CD BioGlyco provides cell surface glycoprotein glycoengineering service that modifies the structure and composition of glycoproteins on the cell surface to regulate cell recognition, adhesion, and migration, providing support for biomedical research.

Cell Surface Blood Group Antigens Glycoengineering Service

At CD BioGlyco, cell surface blood group antigens glycoengineering service provides customized blood group antigen structures for applications in blood typing, organ transplantation, and other areas.

Cell Surface Sialic Acid Glycoengineering Service

At CD BioGlyco, cell surface sialic acid glycoengineering service provides customized sialic acid structures to regulate cell growth, differentiation, immune response, and other functions, offering strong support for drug development and biomedical research.

Publication

Published Data

Technology: Enzymatic glycoengineering approach

Journal: Nature Communications

IF: 17.694

Published: 2022

Results: The authors employed an enzymatic engineering method to transform an N-linked glycoprotein into a laminin-binding glycoprotein, specifically recognized by IIH6. By applying this technique, they successfully restored infection with a lassa-pseudovirus in cells lacking either α-dystroglycan or O-mannosylation. Additionally, viral infection in wildtype cells was effectively inhibited by free matriglycan in a dose-dependent manner, with the length of the matriglycan playing a crucial role.

Here are some of the results shown in this article:

Fig.3 Cell surface glycan engineering of matriglycan. (Sheikh, et al., 2022)

Applications

Biopharmaceutical development: Cell Surface Glycoengineering Service is employed to enhance the glycosylation patterns of host cells used in the production of therapeutic proteins, improving product quality and bioactivity.
Vaccine development: Glycan engineering on cell surfaces is utilized to develop vaccine candidates that can mimic pathogen-specific glycan structures, improving the effectiveness of the immune response.
Cancer research: This service allows researchers to modify glycan profiles on cancer cell surfaces to investigate the role of specific glycans in tumor progression, metastasis, and immune evasion.
Stem cell therapies: By engineering cell surface glycans, it's possible to enhance the homing and integration of stem cells in target tissues, making stem cell-based therapies more effective.

Advantages

Our experienced team of scientists and researchers are leaders in the field of glycoengineering. They bring a wealth of knowledge and expertise to each project, ensuring optimal results.
We are committed to meeting your project timelines. Our efficient processes and project management ensure the timely delivery of results without compromising quality.
Our powerful Glycoengineering Platform allows for the customization of glycoengineering strategies to meet your specific research goals.

CD BioGlyco provides systematic overall solutions for Cell Surface Glycoengineering. We believe our cell surface glycoengineering service will meet your research and biotech needs. If you are interested in our services, please do not hesitate to contact us for more details.

References

Nischan, N.; Kohler, J.J. Advances in cell surface glycoengineering reveal biological function. Glycobiology. 2016, 26(8): 789-796.
Sheikh, M.O.; et al. Cell surface glycan engineering reveals that matriglycan alone can recapitulate dystroglycan binding and function. Nature communications. 2022, 13(1): 3617.

This service is for Research Use Only, not intended for any clinical use.