Overview

In contrast to other molecule-based drug delivery systems, glyconanoparticles exhibit distinctive optical, electrical, magnetic, mechanical, and chemical properties, enabling the modulation of surface ligand density through adjustments to their size and shape. Leveraging these attributes, glyconanoparticles offer a novel platform for targeted drug delivery and enhance the bioavailability of therapeutic agents. Notably in cancer therapy, they harness sugar-multivalent interactions to significantly enhance the targeting accuracy of anticancer drug delivery. Consequently, various glyconanoparticle types have been developed for anticancer drug delivery research. CD BioGlyco provides a comprehensive, one-stop service for formulating anticarcinogen-loaded glyconanoparticles, offering robust support for cancer therapy research. Our service is tailored to accommodate all types of anticancer drugs and customizes the glyconanoparticle according to the specific requirements of each compound.

Unlocking Targeted Delivery of Anticancer Drugs Through High-quality Glyconanoparticles

We have extensive research experience in glyconanoparticle formulation and developing high-quality glyconanoparticles to enhance the therapeutic efficacy of anticancer agents by improving their stability, solubility, and targeted delivery to cancer cells. Based on our well-established GlycoNano™ Platform, we offer the following service components:

Glyconanoparticle Development

Types of glyconanoparticles developed include Carbohydrate-based Nanoparticles, Gold Glyconanoparticles, Silver Glyconanoparticles, Magnetic Glyconanoparticle, Quantum Dot (QD) Glyconanoparticle, etc. We specialize in preparing glyconanoparticles using various methods and optimizing various parameters such as monomer, initiator, and temperature. The resulting glyconanoparticles are well characterized and suitable for tumor cell-targeted drug delivery, studying sugar-related biological effects, and cellular imaging.

In addition, Precipitation Polymerization, Inverse Emulsion Polymerization, and other technologies are used to develop Glycol Nanohydrogel for targeted delivery of anticancer drugs.

Characterization of Glyconanoparticles

We perform detailed characterization of the Physicochemical Properties and Interactions of the developed glyconanoparticles, and specific tests include the following:

• Particle size and morphology are measured using techniques such as transmission electron microscopy (TEM), dynamic light scattering (DLS), etc.
• We determine the surface charge by zeta potential measurements to assess stability.
• Fourier transform infrared spectroscopy (FTIR) is used to detect functional groups contained in the glyconanoparticle.
• Glyconanoparticle binding affinity and interactions with other molecules are also examined.

Preclinical Studies of Glyconanoparticle

We have a wealth of In Vivo and In Vitro Models to validate the developed glyconanoparticle in targeted delivery of anticancer drugs. Specific preclinical studies include Stability testing, biocompatibility, and Safety assessments, Biological Characterization, and Pharmacodynamic and Pharmacokinetic studies.

Our services include, but are not limited to, the following drugs:

Workflow

We provide an anticarcinogen-loaded glyconanoparticle formulation service according to the specific requirements of our clients and their research objectives, which includes adjustments to particle size, surface characteristics, drug loading efficiency, release profiles, etc. Various glyconanoparticles selectively interact with tissues, or cells, and are investigated as targeted anticancer drug delivery systems to improve the efficiency of cancer therapy.

Applications

• Glyconanoparticles offer the possibility of improving the effectiveness of cancer treatment by increasing the solubility and bioavailability of anticancer substances.
• Glyconanoparticles are used to co-deliver multiple anticancer agents or in combination with other therapeutic agents, resulting in a synergistic effect and improved therapeutic efficacy.
• Glyconanoparticles are also used as imaging agents in studies such as cancer diagnostics.

Advantages

• We design glyconanoparticles targeting specific cancer cells, minimizing the impact on healthy tissue. This selective targeting helps to increase the concentration of anticancer substances at the tumor site, thus improving the therapeutic effect.
• We tailor our experimental protocols to meet the specific needs of our clients and provide high-quality after-sales service.
• We combine various advanced technologies for detailed characterization and preclinical studies of glyconanoparticles.

Publication Data

Frequently Asked Questions

• What are the advantages of glyconanoparticles over conventional drug formulations in delivering anticancer drugs?
  • It improves the targeting of cancer cells and reduces damage to healthy tissues.
  • It improves the solubility and bioavailability of poorly soluble drugs.
  • It controls the release of anticancer drugs for sustained action.
  • It has the potential for multifunctional applications (e.g., imaging and therapeutics).
• What types of glyconanoparticle assays and characterizations do you offer?
  To ensure the effective use of glyconanoparticles in anticancer drug delivery, we perform a detailed analysis of their properties and interactions, including particle size, surface charge, drug loading, release kinetics, stability, and more. In addition to this, we conduct comprehensive efficacy, pharmacokinetic, and safety studies using in vitro and in vivo models.

At CD BioGlyco, our anticarcinogen-loaded glyconanoparticle formulation service offers new options for improving the efficacy and reducing the toxicity of cancer therapies. Welcome to contact us to discuss your research needs and detailed experimental plans. We are always happy to discuss cancer treatment strategies and enhance the innovation potential.