Neutral non-fucosylated HMOs involve a wide range of research fields, including infant intestinal flora balance, improving immunity, food processing, etc., and have high market development potential. CD BioGlyco has always been committed to cutting-edge scientific research and product development in the field of nutrition, providing you with one-stop production services of neutral non-fucosylated HMO.
Human milk oligosaccharides (HMOs), functional oligosaccharides with diverse structures, have substantially positive effects on neonatal development, the nervous system, digestive system, immune system, etc. At present, more than 200 kinds of HMOs have been identified. According to different modified genes, HMOs can be divided into three types: neutral fucosylated HMOs, neutral non-fucosylated HMOs, and sialylated acidic HMOs, of which the proportion of neutral HMOs is up to 75%. Neutral non-fucosylated HMO has many potential applications in infant milk powder, dietary supplements, and healthy food for the elderly and lactating women.
Fig.1 HMO structural subtypes. (Sekerel,et al., 2021)
Neutral non-fucosylated HMOs include lactose (Lac), lacto-N-tetraose (LNT), lacto-N-biose (LNB), N-acetyllactosamine (LacNAc), lacto-N-neotetraose (LNnT) and other oligosaccharides. It has a variety of biological activities, some of which are listed as follows:
Promote the growth and development of infants.
Neutral non-fucosyl HMOs help to absorb minerals and regulate the balance of intestinal flora. For example, LNB is a highly specific natural prebiotic for Bifidobacteria and LacNAc is a constituent of glycoproteins and glycolipids in the gastrointestinal tract.
LNnT and its derivatives can stimulate type II immunity by increasing the number of Grl cells and antigen-presenting cells.
Lac reacts with amino compounds such as protein, peptide, or amino acid under heating conditions to produce caramel color or brown flavor, which can be used in the production of baked food and flavoring products.
CD BioGlyco has accumulated a variety of production methods, including chemical synthesis, separation and purification, whole-cell biotransformation (fermentation), enzyme catalysis (isolated enzyme biotransformation), and chemoenzymatic methods. The neutral non-fucosylated HMOs we have produced include but are not limited to the types listed in the following table, and we are also expanding the production of new types of neutral non-fucosylated HMOs.
CD BioGlyco is the world's leading supplier of neutral non-fucosylated HMOs. We have achieved fruitful results in maternal and infant health research projects at home and abroad. If you are interested in our services, please contact us feel free.
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